A randomized controlled trial comparing autologous radiolabeled in vivo platelet (PLT) recoveries and survivals of 7-day-stored PLT-rich plasma and buffy coat PLTs from the same subjects

• Published in: Transfusion (Philadelphia, Pa.) Vol. 51; no. 6; pp. 1241 - 1248
• Main Authors: Dumont, Larry J., Dumont, Deborah F., Unger, Zoe M., Siegel, Alan, Szczepiorkowski, Zbigniew M., Corson, Jill S., Jones, Mary Kay, Christoffel, Todd, Pellham, Esther, Bailey, S. Lawrence, Slichter, Sherrill J.
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.06.2011; Wiley
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Blood coagulation. Blood cells; Blood Platelets - cytology; Blood Preservation - adverse effects; Blood Preservation - methods; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis; Fundamental and applied biological sciences. Psychology; Humans; Medical sciences; Molecular and cellular biology; Platelet; Platelet-Rich Plasma - cytology; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Human; Platelet; Autologous system; Transfusion; Survival; Conservation

BACKGROUND: A recent review concluded that there was inadequate evidence to show a difference between buffy coat (BC) and platelet (PLT)‐rich plasma (PRP) PLT concentrates prepared from whole blood. We hypothesized that 7‐day‐stored BC‐PLTs would have superior autologous recoveries and survivals com...