NEGATIVE REGULATION OF QUINONE REDUCTASE 2 BY RESVERATROL IN CULTURED VASCULAR SMOOTH MUSCLE CELLS

• Published in: Clinical and experimental pharmacology & physiology Vol. 35; no. 12; pp. 1419 - 1425
• Main Authors: Cai, Jing-Bo, Zhang, Zhi-Hua, Xu, Dong-Jie, Qian, Zhi-Yong, Wang, Zhi-Rong, Huang, Yuan-Zhu, Zou, Jian-Gang, Cao, Ke-Jiang
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01.12.2008
• Subjects: Animals; Aorta, Thoracic - drug effects; Aorta, Thoracic - enzymology; Cells, Cultured; Dose-Response Relationship, Drug; Down-Regulation - drug effects; Down-Regulation - physiology; Enzyme Inhibitors - pharmacology; lentiviral vector; Male; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - enzymology; quinone reductase type 2 (NQO2); Quinone Reductases - antagonists & inhibitors; Quinone Reductases - biosynthesis; Quinone Reductases - physiology; Rabbits; Rats; Rats, Sprague-Dawley; resveratrol; resveratrol-targeting protein; RNA interference; Stilbenes - pharmacology; Time Factors; vascular smooth muscle cells; Vitaceae

SUMMARY 1 Resveratrol, a polyphenol in red wine, has a cardioprotective effect. Resveratrol‐targeting protein (RTP) has been purified using a resveratrol affinity column (RAC) and has been identified as quinone reductase type 2 (NQO2). We hypothesize that NQO2 is the target protein of resveratrol in...