The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation

• Published in: iScience Vol. 11; pp. 160 - 177
• Main Authors: Baranov, Maksim V., Bianchi, Frans, Schirmacher, Anastasiya, van Aart, Melissa A.C., Maassen, Sjors, Muntjewerff, Elke M., Dingjan, Ilse, ter Beest, Martin, Verdoes, Martijn, Keyser, Samantha G.L., Bertozzi, Carolyn R., Diederichsen, Ulf, van den Bogaart, Geert
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 25.01.2019; Elsevier
• Subjects: Immune Response; Immunology; Molecular Mechanism of Gene Regulation; Molecular Mechanism of Gene Regulation; Immune Response; Immunology

Antigen presentation to T cells in major histocompatibility complex class II (MHC class II) requires the conversion of early endo/phagosomes into lysosomes by a process called maturation. Maturation is driven by the phosphoinositide kinase PIKfyve. Blocking PIKfyve activity by small molecule inhibit...