Hydro-ethanolic extract of cashew tree (Anacardium occidentale) nut and its principal compound, anacardic acid, stimulate glucose uptake in C2C12 muscle cells

• Published in: Molecular nutrition & food research Vol. 54; no. 12; pp. 1753 - 1762
• Main Authors: Tedong, Leonard, Madiraju, Padma, Martineau, Louis C, Vallerand, Diane, Arnason, John T, Desire, Dzeufiet D.P, Lavoie, Louis, Kamtchouing, Pierre, Haddad, Pierre S
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley-VCH Verlag 01.12.2010; WILEY-VCH Verlag; WILEY‐VCH Verlag; Wiley
• Subjects: Acetyl-CoA carboxylase; Adenosine monophosphate-activated protein kinase; Anacardic acid; Anacardic Acids - pharmacology; Anacardium - chemistry; Analysis of Variance; Animals; Biological and medical sciences; Blotting, Western; Cashew seed extract; Cell Line; Diabetes; Food industries; Fruit and vegetable industries; Fundamental and applied biological sciences. Psychology; Glucose - metabolism; Hypoglycemic Agents - pharmacology; Insulin - metabolism; Male; Mice; Mitochondria, Liver - drug effects; Muscle Cells - cytology; Muscle Cells - metabolism; Muscle Fibers, Skeletal - cytology; Nuts - chemistry; Oxidative Phosphorylation; Plant Extracts - pharmacology; Proto-Oncogene Proteins c-akt - metabolism; Rats; Rats, Wistar; Receptor, Insulin - metabolism; Seeds - chemistry; Nuts; Seeds; Cashew seed extract; Enzyme; Anacardium occidentale; Adenosine monophosphate-activated protein kinase; Transferases; Non-specific serine/threonine protein kinase; Extract; Glucose; Uptake; Anacardic acid; Acetyl-CoA carboxylase; Dicotyledones; Angiospermae; Tree; Carbohydrate; Spermatophyta; Muscle; Diabetes; Anacardiaceae

Scope: Products of cashew tree (Anacardium occidentale) are used in traditional medicine for various ailments, including diabetes. Methods and results: The anti-diabetic properties of cashew plant parts were studied using differentiated C2C12 myoblasts (myotubes) and rat liver mitochondria. Hydroeth...