Application of a 4-h human patch test method for comparative and investigative assessment of skin irritation

• Published in: Contact dermatitis Vol. 38; no. 4; pp. 194 - 202
• Main Authors: Robinson, Michael K., Perkins, Mary A., Basketter, David A.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.04.1998; Blackwell
• Subjects: 1-decanol; acetic acid; Acetic Acid - adverse effects; Allergic diseases; Asian Continental Ancestry Group; Biological and medical sciences; chemicals; Dermatitis, Allergic Contact - etiology; European Continental Ancestry Group; Fatty Alcohols - adverse effects; human; Humans; Immunopathology; irritancy; irritant contact dermatitis; Irritants - adverse effects; Medical sciences; neurosensitivity; patch testing; Patch Tests - methods; racial; Skin allergic diseases. Stinging insect allergies; sodium dodecyl sulfate; Sodium Dodecyl Sulfate - adverse effects; sodium hydroxide; Sodium Hydroxide - adverse effects; Time Factors; Human; Skin disease; Investigation method; Chemical compound; Multicenter study; Interindividual comparison; Race; Irritant compound; Patch; Skin test

A human 4‐h patch test has recently been developed for testing the irritation hazard potential of chemicals. The original method was developed for comparative irritation assessments relative to benchmark irritants using simple statistical tests. In this context, the method has been shown to be robus...