Endothelin receptors blockade blunts hypoxia-induced increase in PAP in humans

• Published in: European journal of clinical investigation Vol. 40; no. 3; pp. 195 - 202
• Main Authors: Pham, I., Wuerzner, G., Richalet, J.-P., Peyrard, S., Azizi, M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.03.2010; Wiley-Blackwell
• Subjects: Administration, Oral; Adult; Antihypertensive Agents - administration & dosage; Antihypertensive Agents - pharmacology; Biological and medical sciences; Blood Gas Analysis; Blood Pressure - drug effects; Cardiac Output - drug effects; Cross-Over Studies; Double-Blind Method; Echocardiography; Endothelin Receptor Antagonists; Endothelin-1; Exercise - physiology; General aspects; Humans; hypoxia; Hypoxia - drug therapy; Hypoxia - physiopathology; Male; Medical sciences; Middle Aged; Oxygen - metabolism; Pneumology; Pulmonary Artery - drug effects; Pulmonary Circulation - drug effects; pulmonary hypertension; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases; Sulfonamides - administration & dosage; Sulfonamides - pharmacology; Human; Medicine; Oxygen; Respiratory disease; Blunted effect; Endothelin-1; Cardiovascular disease; Hypoxia; Increase; Endothelin 1; Pulmonary hypertension; Endothelin receptor

Eur J Clin Invest 2010; 40 (3): 195–202 Background  Activation of the endothelin‐1 (ET‐1) pathway may be involved in hypoxia‐induced pulmonary vasoconstriction, increase in pulmonary pressure and high altitude pulmonary oedema. Thus, we investigated the effect of the ETA/ETB receptor antagonist, bos...