Expression of COX-1, COX-2, and PPAR-γ in the gastric mucosa of children with Helicobacter pylori infection
Background: Gastric inflammation in patients with Helicobacter pylori infection is considered to be regulated by many kinds of inflammatory and cytoprotective factors. The present study examined the effects of cyclo‐oxygenase (COX)‐1, ‐2, and peroxisome proliferator‐activated receptor‐γ (PPAR‐γ) on...
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| Published in | Pediatrics international Vol. 50; no. 1; pp. 1 - 6 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Melbourne, Australia
Blackwell Publishing Asia
01.02.2008
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1328-8067 1442-200X |
| DOI | 10.1111/j.1442-200X.2007.02504.x |
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| Abstract | Background: Gastric inflammation in patients with Helicobacter pylori infection is considered to be regulated by many kinds of inflammatory and cytoprotective factors. The present study examined the effects of cyclo‐oxygenase (COX)‐1, ‐2, and peroxisome proliferator‐activated receptor‐γ (PPAR‐γ) on gastric mucosal injury in children with H. pylori infection.
Methods: The subjects were 24 children who underwent endoscopy for the evaluation of anemia or gastrointestinal symptoms, and they were divided into two groups: a H. pylori‐positive group and ‐negative group. The numbers of neutrophils in the gastric mucosa of children with and without H. pylori infection and expression of COX‐1, ‐2, and PPAR‐γ were examined, using reverse transcription–polymerase chain reaction.
Results: The numbers of neutrophils were significantly higher in the H. pylori‐positive group than in the H. pylori‐negative group. The ratio of COX‐1 mRNA to COX‐2 mRNA in the H. pylori‐positive group was significantly lower than that in the H. pylori‐negative group. The ratio of PPAR‐γ m‐RNA to β‐actin mRNA was significantly higher in the H. pylori‐positive group than the H. pylori‐negative group.
Conclusions: Enhanced production of COX‐2 and PPAR‐γ in the gastric mucosa has cytoprotective and anti‐inflammatory effects, although the relationship to the carcinogenic activity of COX‐2 and PPAR‐γ should be clarified. |
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| AbstractList | Background:
Gastric inflammation in patients with
Helicobacter pylori
infection is considered to be regulated by many kinds of inflammatory and cytoprotective factors. The present study examined the effects of cyclo‐oxygenase (COX)‐1, ‐2, and peroxisome proliferator‐activated receptor‐γ (PPAR‐γ) on gastric mucosal injury in children with
H. pylori
infection.
Methods:
The subjects were 24 children who underwent endoscopy for the evaluation of anemia or gastrointestinal symptoms, and they were divided into two groups: a
H. pylori
‐positive group and ‐negative group. The numbers of neutrophils in the gastric mucosa of children with and without
H. pylori
infection and expression of COX‐1, ‐2, and PPAR‐γ were examined, using reverse transcription–polymerase chain reaction.
Results:
The numbers of neutrophils were significantly higher in the
H. pylori
‐positive group than in the
H. pylori
‐negative group. The ratio of COX‐1 mRNA to COX‐2 mRNA in the
H. pylori
‐positive group was significantly lower than that in the
H. pylori
‐negative group. The ratio of PPAR‐γ m‐RNA to β‐actin mRNA was significantly higher in the
H. pylori
‐positive group than the
H. pylori
‐negative group.
Conclusions:
Enhanced production of COX‐2 and PPAR‐γ in the gastric mucosa has cytoprotective and anti‐inflammatory effects, although the relationship to the carcinogenic activity of COX‐2 and PPAR‐γ should be clarified. Gastric inflammation in patients with Helicobacter pylori infection is considered to be regulated by many kinds of inflammatory and cytoprotective factors. The present study examined the effects of cyclo-oxygenase (COX)-1, -2, and peroxisome proliferator-activated receptor-gamma (PPAR-gamma) on gastric mucosal injury in children with H. pylori infection. The subjects were 24 children who underwent endoscopy for the evaluation of anemia or gastrointestinal symptoms, and they were divided into two groups: a H. pylori-positive group and -negative group. The numbers of neutrophils in the gastric mucosa of children with and without H. pylori infection and expression of COX-1, -2, and PPAR-gamma were examined, using reverse transcription-polymerase chain reaction. The numbers of neutrophils were significantly higher in the H. pylori-positive group than in the H. pylori-negative group. The ratio of COX-1 mRNA to COX-2 mRNA in the H. pylori-positive group was significantly lower than that in the H. pylori-negative group. The ratio of PPAR-gamma m-RNA to beta-actin mRNA was significantly higher in the H. pylori-positive group than the H. pylori-negative group. Enhanced production of COX-2 and PPAR-gamma in the gastric mucosa has cytoprotective and anti-inflammatory effects, although the relationship to the carcinogenic activity of COX-2 and PPAR-gamma should be clarified. Background: Gastric inflammation in patients with Helicobacter pylori infection is considered to be regulated by many kinds of inflammatory and cytoprotective factors. The present study examined the effects of cyclo‐oxygenase (COX)‐1, ‐2, and peroxisome proliferator‐activated receptor‐γ (PPAR‐γ) on gastric mucosal injury in children with H. pylori infection. Methods: The subjects were 24 children who underwent endoscopy for the evaluation of anemia or gastrointestinal symptoms, and they were divided into two groups: a H. pylori‐positive group and ‐negative group. The numbers of neutrophils in the gastric mucosa of children with and without H. pylori infection and expression of COX‐1, ‐2, and PPAR‐γ were examined, using reverse transcription–polymerase chain reaction. Results: The numbers of neutrophils were significantly higher in the H. pylori‐positive group than in the H. pylori‐negative group. The ratio of COX‐1 mRNA to COX‐2 mRNA in the H. pylori‐positive group was significantly lower than that in the H. pylori‐negative group. The ratio of PPAR‐γ m‐RNA to β‐actin mRNA was significantly higher in the H. pylori‐positive group than the H. pylori‐negative group. Conclusions: Enhanced production of COX‐2 and PPAR‐γ in the gastric mucosa has cytoprotective and anti‐inflammatory effects, although the relationship to the carcinogenic activity of COX‐2 and PPAR‐γ should be clarified. AbstractBackground: Gastric inflammation in patients with Helicobacter pylori infection is considered to be regulated by many kinds of inflammatory and cytoprotective factors. The present study examined the effects of cyclo-oxygenase (COX)-1, -2, and peroxisome proliferator-activated receptor- gamma (PPAR- gamma ) on gastric mucosal injury in children with H. pylori infection.Methods: The subjects were 24 children who underwent endoscopy for the evaluation of anemia or gastrointestinal symptoms, and they were divided into two groups: a H. pylori-positive group and -negative group. The numbers of neutrophils in the gastric mucosa of children with and without H. pylori infection and expression of COX-1, -2, and PPAR- gamma were examined, using reverse transcription-polymerase chain reaction.Results: The numbers of neutrophils were significantly higher in the H. pylori-positive group than in the H. pylori-negative group. The ratio of COX-1 mRNA to COX-2 mRNA in the H. pylori-positive group was significantly lower than that in the H. pylori-negative group. The ratio of PPAR- gamma m-RNA to beta -actin mRNA was significantly higher in the H. pylori-positive group than the H. pylori-negative group.Conclusions: Enhanced production of COX-2 and PPAR- gamma in the gastric mucosa has cytoprotective and anti-inflammatory effects, although the relationship to the carcinogenic activity of COX-2 and PPAR- gamma should be clarified. Gastric inflammation in patients with Helicobacter pylori infection is considered to be regulated by many kinds of inflammatory and cytoprotective factors. The present study examined the effects of cyclo-oxygenase (COX)-1, -2, and peroxisome proliferator-activated receptor-gamma (PPAR-gamma) on gastric mucosal injury in children with H. pylori infection.BACKGROUNDGastric inflammation in patients with Helicobacter pylori infection is considered to be regulated by many kinds of inflammatory and cytoprotective factors. The present study examined the effects of cyclo-oxygenase (COX)-1, -2, and peroxisome proliferator-activated receptor-gamma (PPAR-gamma) on gastric mucosal injury in children with H. pylori infection.The subjects were 24 children who underwent endoscopy for the evaluation of anemia or gastrointestinal symptoms, and they were divided into two groups: a H. pylori-positive group and -negative group. The numbers of neutrophils in the gastric mucosa of children with and without H. pylori infection and expression of COX-1, -2, and PPAR-gamma were examined, using reverse transcription-polymerase chain reaction.METHODSThe subjects were 24 children who underwent endoscopy for the evaluation of anemia or gastrointestinal symptoms, and they were divided into two groups: a H. pylori-positive group and -negative group. The numbers of neutrophils in the gastric mucosa of children with and without H. pylori infection and expression of COX-1, -2, and PPAR-gamma were examined, using reverse transcription-polymerase chain reaction.The numbers of neutrophils were significantly higher in the H. pylori-positive group than in the H. pylori-negative group. The ratio of COX-1 mRNA to COX-2 mRNA in the H. pylori-positive group was significantly lower than that in the H. pylori-negative group. The ratio of PPAR-gamma m-RNA to beta-actin mRNA was significantly higher in the H. pylori-positive group than the H. pylori-negative group.RESULTSThe numbers of neutrophils were significantly higher in the H. pylori-positive group than in the H. pylori-negative group. The ratio of COX-1 mRNA to COX-2 mRNA in the H. pylori-positive group was significantly lower than that in the H. pylori-negative group. The ratio of PPAR-gamma m-RNA to beta-actin mRNA was significantly higher in the H. pylori-positive group than the H. pylori-negative group.Enhanced production of COX-2 and PPAR-gamma in the gastric mucosa has cytoprotective and anti-inflammatory effects, although the relationship to the carcinogenic activity of COX-2 and PPAR-gamma should be clarified.CONCLUSIONSEnhanced production of COX-2 and PPAR-gamma in the gastric mucosa has cytoprotective and anti-inflammatory effects, although the relationship to the carcinogenic activity of COX-2 and PPAR-gamma should be clarified. |
| Author | Ohtsuka, Yoshikazu Yarita, Yukiko Yamashiro, Yuichiro Haruna, Hidenori Fujii, Tohru Kudo, Takahiro Shimizu, Toshiaki |
| Author_xml | – sequence: 1 givenname: Hidenori surname: Haruna fullname: Haruna, Hidenori organization: Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan – sequence: 2 givenname: Toshiaki surname: Shimizu fullname: Shimizu, Toshiaki email: tshimizu@med.juntendo.ac.jp organization: Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan – sequence: 3 givenname: Yoshikazu surname: Ohtsuka fullname: Ohtsuka, Yoshikazu organization: Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan – sequence: 4 givenname: Yukiko surname: Yarita fullname: Yarita, Yukiko organization: Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan – sequence: 5 givenname: Tohru surname: Fujii fullname: Fujii, Tohru organization: Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan – sequence: 6 givenname: Takahiro surname: Kudo fullname: Kudo, Takahiro organization: Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan – sequence: 7 givenname: Yuichiro surname: Yamashiro fullname: Yamashiro, Yuichiro organization: Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18279196$$D View this record in MEDLINE/PubMed |
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| Snippet | Background: Gastric inflammation in patients with Helicobacter pylori infection is considered to be regulated by many kinds of inflammatory and cytoprotective... Background: Gastric inflammation in patients with Helicobacter pylori infection is considered to be regulated by many kinds of inflammatory and cytoprotective... Gastric inflammation in patients with Helicobacter pylori infection is considered to be regulated by many kinds of inflammatory and cytoprotective factors. The... AbstractBackground: Gastric inflammation in patients with Helicobacter pylori infection is considered to be regulated by many kinds of inflammatory and... |
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| SubjectTerms | Adolescent Child Child, Preschool COX Cyclooxygenase 1 - analysis Cyclooxygenase 2 - analysis Female gastric mucosa Gastric Mucosa - chemistry Helicobacter Infections - metabolism Helicobacter pylori Humans Infant Male mRNA expression PPAR gamma - analysis PPAR-γ RNA, Messenger - analysis |
| Title | Expression of COX-1, COX-2, and PPAR-γ in the gastric mucosa of children with Helicobacter pylori infection |
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