Differential expression of interleukin-10 mRNA in Wallerian degeneration and immune-mediated inflammation of the rat peripheral nervous system

• Published in: Journal of neuroscience research Vol. 43; no. 2; pp. 254 - 259
• Main Authors: Jander, S., Pohl, J., Gillen, C., Stoll, G.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 15.01.1996
• Subjects: Animals; axotomy; DNA Probes; experimental autoimmune neuritis; Female; Immunohistochemistry; In Situ Hybridization; Interleukin-10 - biosynthesis; macrophage; Macrophages - drug effects; Macrophages - metabolism; Neuritis - immunology; Neuritis - metabolism; Neuritis - pathology; Peripheral Nervous System - metabolism; Peripheral Nervous System - pathology; Rats; Rats, Inbred Lew; RNA, Messenger - biosynthesis; Schwann cell; Schwann Cells - drug effects; Schwann Cells - metabolism; Wallerian Degeneration - drug effects

Interleukin‐10 (IL‐10) is a potent immunosuppressant cytokine which downregulates MHC class II antigen expression and inflammatory cytokine production. In this study we localized mRNA for IL‐10 in the rat peripheral nervous system (PNS) by nonradioactive in situ hybridization using a digoxygenin‐lab...