Autocrine/paracrine mechanism of insulin-like growth factor-1 secretion, and the effect of insulin-like growth factor-1 on proteoglycan synthesis in bovine intervertebral discs

• Published in: Journal of orthopaedic research Vol. 14; no. 5; p. 690
• Main Authors: Osada, R, Ohshima, H, Ishihara, H, Yudoh, K, Sakai, K, Matsui, H, Tsuji, H
• Format: Journal Article
• Language: English
• Published: United States 01.09.1996
• Subjects: Age Factors; Animals; Cattle; Cells, Cultured - drug effects; Cells, Cultured - metabolism; Cells, Cultured - secretion; Coccyx; Extracellular Matrix - drug effects; Extracellular Matrix - metabolism; Gene Expression - drug effects; Insulin-Like Growth Factor I - genetics; Insulin-Like Growth Factor I - pharmacology; Insulin-Like Growth Factor I - secretion; Intervertebral Disc - chemistry; Intervertebral Disc - cytology; Intervertebral Disc - metabolism; Iodine Radioisotopes; Protein Binding - physiology; Proteoglycans - biosynthesis; Proteoglycans - drug effects; Receptor, IGF Type 1 - analysis; RNA, Messenger - metabolism

The present study was undertaken to investigate the effect of insulin-like growth factor-1 on proteoglycan synthesis and the autocrine/paracrine mechanism involving insulin-like growth factor-1 in the bovine coccygeal intervertebral disc. Insulin-like growth factor-1 stimulated proteoglycan synthesi...