Renal endothelin system and excretory function in Wistar-Kyoto and Long-Evans rats
Aim: The role of the kidney endothelin system in the renal regulation of fluid and electrolyte excretion was investigated in Wistar–Kyoto (WKY) and Long–Evans (LE) rats in which we found previously marked differences in the renal excretory responses to endothelin A receptor blockade. Methods: The...
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Published in | Acta Physiologica Vol. 186; no. 1; pp. 67 - 76 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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Oxford, UK
Blackwell Science Ltd
01.01.2006
Blackwell |
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Abstract | Aim: The role of the kidney endothelin system in the renal regulation of fluid and electrolyte excretion was investigated in Wistar–Kyoto (WKY) and Long–Evans (LE) rats in which we found previously marked differences in the renal excretory responses to endothelin A receptor blockade.
Methods: The selective endothelin A and B receptor antagonists BQ‐123 (16.4 nmol kg−1 min−1) and BQ‐788 (25 nmol kg−1 min−1) were infused i.v. for 50 min in conscious chronically instrumented WKY and LE rats and their renal function and renal endothelin system were studied.
Results: Without effects on glomerular filtration rate or renal blood flow, BQ‐123 and BQ‐788 decreased by more than 50% (P < 0.01) both urine flow rate and electrolyte excretion in WKY rats but only urine flow rate (P < 0.05) in LE rats. Endothelin‐1 content, preproET‐1/GPDH mRNA ratio, Bmax and Kd of total endothelin receptors in renal cortex did not differ between the two strains. In contrast, plasma endothelin‐1 concentration (0.58 ± 0.04 vs. 1.05 ± 0.01 femtomol mL−1; P < 0.01), renal papillary ET‐1 concentration (68 ± 5 vs. 478 ± 62 fmol mg−1 protein; P < 0.01) and preproET‐1/GPDH mRNA ratio (0.65 ± 0.09 vs. 0.88 ± 0.05; P < 0.05) as well as total endothelin receptor number in renal papilla (Bmax 5.3 ± 0.4 vs. and 9.0 ± 1.2 pmol mg−1 protein; P < 0.05) were markedly lower in LE than in WKY rats. In vitro studies showed that in both strains ETB receptors on renal cortical membranes amounted between 65% and 67% and on papillary membranes between 85% and 88%.
Conclusion: The present data show that the selective ETA or ETB receptor blockade differentially affects tubular water and salt handling, which becomes apparent in conditions of low renal papillary endothelin receptor number and tissue endothelin‐1 concentration. |
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AbstractList | The role of the kidney endothelin system in the renal regulation of fluid and electrolyte excretion was investigated in Wistar-Kyoto (WKY) and Long-Evans (LE) rats in which we found previously marked differences in the renal excretory responses to endothelin A receptor blockade.
The selective endothelin A and B receptor antagonists BQ-123 (16.4 nmol kg(-1) min(-1)) and BQ-788 (25 nmol kg(-1) min(-1)) were infused i.v. for 50 min in conscious chronically instrumented WKY and LE rats and their renal function and renal endothelin system were studied.
Without effects on glomerular filtration rate or renal blood flow, BQ-123 and BQ-788 decreased by more than 50% (P < 0.01) both urine flow rate and electrolyte excretion in WKY rats but only urine flow rate (P < 0.05) in LE rats. Endothelin-1 content, preproET-1/GPDH mRNA ratio, B(max) and K(d) of total endothelin receptors in renal cortex did not differ between the two strains. In contrast, plasma endothelin-1 concentration (0.58 +/- 0.04 vs. 1.05 +/- 0.01 femtomol mL(-1); P < 0.01), renal papillary ET-1 concentration (68 +/- 5 vs. 478 +/- 62 fmol mg(-1) protein; P < 0.01) and preproET-1/GPDH mRNA ratio (0.65 +/- 0.09 vs. 0.88 +/- 0.05; P < 0.05) as well as total endothelin receptor number in renal papilla (B(max) 5.3 +/- 0.4 vs. and 9.0 +/- 1.2 pmol mg(-1) protein; P < 0.05) were markedly lower in LE than in WKY rats. In vitro studies showed that in both strains ET(B) receptors on renal cortical membranes amounted between 65% and 67% and on papillary membranes between 85% and 88%.
The present data show that the selective ET(A) or ET(B) receptor blockade differentially affects tubular water and salt handling, which becomes apparent in conditions of low renal papillary endothelin receptor number and tissue endothelin-1 concentration. Abstract Aim: The role of the kidney endothelin system in the renal regulation of fluid and electrolyte excretion was investigated in Wistar–Kyoto (WKY) and Long–Evans (LE) rats in which we found previously marked differences in the renal excretory responses to endothelin A receptor blockade. Methods: The selective endothelin A and B receptor antagonists BQ‐123 (16.4 nmol kg −1 min −1 ) and BQ‐788 (25 nmol kg −1 min −1 ) were infused i.v. for 50 min in conscious chronically instrumented WKY and LE rats and their renal function and renal endothelin system were studied. Results: Without effects on glomerular filtration rate or renal blood flow, BQ‐123 and BQ‐788 decreased by more than 50% ( P < 0.01) both urine flow rate and electrolyte excretion in WKY rats but only urine flow rate ( P < 0.05) in LE rats. Endothelin‐1 content, preproET‐1/GPDH mRNA ratio, B max and K d of total endothelin receptors in renal cortex did not differ between the two strains. In contrast, plasma endothelin‐1 concentration (0.58 ± 0.04 vs. 1.05 ± 0.01 femtomol mL −1 ; P < 0.01), renal papillary ET‐1 concentration (68 ± 5 vs. 478 ± 62 fmol mg −1 protein; P < 0.01) and preproET‐1/GPDH mRNA ratio (0.65 ± 0.09 vs. 0.88 ± 0.05; P < 0.05) as well as total endothelin receptor number in renal papilla ( B max 5.3 ± 0.4 vs. and 9.0 ± 1.2 pmol mg −1 protein; P < 0.05) were markedly lower in LE than in WKY rats. In vitro studies showed that in both strains ET B receptors on renal cortical membranes amounted between 65% and 67% and on papillary membranes between 85% and 88%. Conclusion: The present data show that the selective ET A or ET B receptor blockade differentially affects tubular water and salt handling, which becomes apparent in conditions of low renal papillary endothelin receptor number and tissue endothelin‐1 concentration. AIMThe role of the kidney endothelin system in the renal regulation of fluid and electrolyte excretion was investigated in Wistar-Kyoto (WKY) and Long-Evans (LE) rats in which we found previously marked differences in the renal excretory responses to endothelin A receptor blockade.METHODSThe selective endothelin A and B receptor antagonists BQ-123 (16.4 nmol kg(-1) min(-1)) and BQ-788 (25 nmol kg(-1) min(-1)) were infused i.v. for 50 min in conscious chronically instrumented WKY and LE rats and their renal function and renal endothelin system were studied.RESULTSWithout effects on glomerular filtration rate or renal blood flow, BQ-123 and BQ-788 decreased by more than 50% (P < 0.01) both urine flow rate and electrolyte excretion in WKY rats but only urine flow rate (P < 0.05) in LE rats. Endothelin-1 content, preproET-1/GPDH mRNA ratio, B(max) and K(d) of total endothelin receptors in renal cortex did not differ between the two strains. In contrast, plasma endothelin-1 concentration (0.58 +/- 0.04 vs. 1.05 +/- 0.01 femtomol mL(-1); P < 0.01), renal papillary ET-1 concentration (68 +/- 5 vs. 478 +/- 62 fmol mg(-1) protein; P < 0.01) and preproET-1/GPDH mRNA ratio (0.65 +/- 0.09 vs. 0.88 +/- 0.05; P < 0.05) as well as total endothelin receptor number in renal papilla (B(max) 5.3 +/- 0.4 vs. and 9.0 +/- 1.2 pmol mg(-1) protein; P < 0.05) were markedly lower in LE than in WKY rats. In vitro studies showed that in both strains ET(B) receptors on renal cortical membranes amounted between 65% and 67% and on papillary membranes between 85% and 88%.CONCLUSIONThe present data show that the selective ET(A) or ET(B) receptor blockade differentially affects tubular water and salt handling, which becomes apparent in conditions of low renal papillary endothelin receptor number and tissue endothelin-1 concentration. Aim: The role of the kidney endothelin system in the renal regulation of fluid and electrolyte excretion was investigated in Wistar–Kyoto (WKY) and Long–Evans (LE) rats in which we found previously marked differences in the renal excretory responses to endothelin A receptor blockade. Methods: The selective endothelin A and B receptor antagonists BQ‐123 (16.4 nmol kg−1 min−1) and BQ‐788 (25 nmol kg−1 min−1) were infused i.v. for 50 min in conscious chronically instrumented WKY and LE rats and their renal function and renal endothelin system were studied. Results: Without effects on glomerular filtration rate or renal blood flow, BQ‐123 and BQ‐788 decreased by more than 50% (P < 0.01) both urine flow rate and electrolyte excretion in WKY rats but only urine flow rate (P < 0.05) in LE rats. Endothelin‐1 content, preproET‐1/GPDH mRNA ratio, Bmax and Kd of total endothelin receptors in renal cortex did not differ between the two strains. In contrast, plasma endothelin‐1 concentration (0.58 ± 0.04 vs. 1.05 ± 0.01 femtomol mL−1; P < 0.01), renal papillary ET‐1 concentration (68 ± 5 vs. 478 ± 62 fmol mg−1 protein; P < 0.01) and preproET‐1/GPDH mRNA ratio (0.65 ± 0.09 vs. 0.88 ± 0.05; P < 0.05) as well as total endothelin receptor number in renal papilla (Bmax 5.3 ± 0.4 vs. and 9.0 ± 1.2 pmol mg−1 protein; P < 0.05) were markedly lower in LE than in WKY rats. In vitro studies showed that in both strains ETB receptors on renal cortical membranes amounted between 65% and 67% and on papillary membranes between 85% and 88%. Conclusion: The present data show that the selective ETA or ETB receptor blockade differentially affects tubular water and salt handling, which becomes apparent in conditions of low renal papillary endothelin receptor number and tissue endothelin‐1 concentration. |
Author | Markova, P. Kramer, H. J. Girchev, R. Bäcker, A. |
Author_xml | – sequence: 1 givenname: R. surname: Girchev fullname: Girchev, R. organization: Department of Physiology, Medical University, Sofia, Bulgaria – sequence: 2 givenname: A. surname: Bäcker fullname: Bäcker, A. organization: Renal Section, Medical Policlinic, University of Bonn, Bonn, Germany – sequence: 3 givenname: P. surname: Markova fullname: Markova, P. organization: Department of Physiology, Medical University, Sofia, Bulgaria – sequence: 4 givenname: H. J. surname: Kramer fullname: Kramer, H. J. organization: Renal Section, Medical Policlinic, University of Bonn, Bonn, Germany |
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CitedBy_id | crossref_primary_10_1080_08860220600778944 crossref_primary_10_1016_j_vascn_2017_02_020 crossref_primary_10_3389_fphys_2022_848867 crossref_primary_10_1152_ajpheart_91477_2007 |
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Keywords | Excretion Endothelin Renal function Rat Hydroelectrolytic balance Rodentia Endothelin 1 renal endothelin ETA endothelin receptor Vertebrata Mammalia BQ-788 renal excretory function Urinary system Long-Evans rat ETB endothelin receptor Wistar-Kyoto rat BQ-123 |
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Snippet | Aim: The role of the kidney endothelin system in the renal regulation of fluid and electrolyte excretion was investigated in Wistar–Kyoto (WKY) and Long–Evans... The role of the kidney endothelin system in the renal regulation of fluid and electrolyte excretion was investigated in Wistar-Kyoto (WKY) and Long-Evans (LE)... Abstract Aim: The role of the kidney endothelin system in the renal regulation of fluid and electrolyte excretion was investigated in Wistar–Kyoto (WKY) and... AIMThe role of the kidney endothelin system in the renal regulation of fluid and electrolyte excretion was investigated in Wistar-Kyoto (WKY) and Long-Evans... |
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SubjectTerms | Animals Biological and medical sciences Blood Pressure - physiology BQ-123 BQ-788 Electrolytes - urine Endothelin A Receptor Antagonists Endothelin B Receptor Antagonists Endothelin-1 - analysis Endothelin-1 - blood Endothelins - physiology Fundamental and applied biological sciences. Psychology Glomerular Filtration Rate - physiology Heart Rate - physiology Infusions, Intravenous Kidney - physiology Kidney Cortex - chemistry Long-Evans rat Male Oligopeptides - administration & dosage Peptides, Cyclic - administration & dosage Piperidines - administration & dosage Rats Rats, Inbred WKY Rats, Long-Evans Renal Circulation - physiology renal endothelin renal excretory function RNA, Messenger - analysis Urination - drug effects Vertebrates: urinary system Wistar-Kyoto rat |
Title | Renal endothelin system and excretory function in Wistar-Kyoto and Long-Evans rats |
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