Computation-Driven Analysis of Model Polyextremo-tolerant Fungus Exophiala dermatitidis: Defensive Pigment Metabolic Costs and Human Applications

• Published in: iScience Vol. 23; no. 4; p. 100980
• Main Authors: Schroeder, Wheaton L., Harris, Steven D., Saha, Rajib
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 24.04.2020; Elsevier
• Subjects: Bioinformatics; Metabolic Engineering; Microbiology; Metabolic Engineering; Microbiology; Bioinformatics

The polyextremotolerant black yeast Exophiala dermatitidis is a tractable model system for investigation of adaptations that support growth under extreme conditions. Foremost among these adaptations are melanogenesis and carotenogenesis. A particularly important question is their metabolic productio...