The C677T polymorphism of the methylenetetrahydrofolate reductase gene and idiopathic recurrent miscarriage

• Published in: Obstetrics and gynecology (New York. 1953) Vol. 99; no. 4; pp. 614 - 619
• Main Authors: Unfried, Gertrud, Griesmacher, Andrea, Weismüller, Wolfgang, Nagele, Fritz, Huber, Johannes C, Tempfer, Clemens B
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.04.2002; The American College of Obstetricians and Gynecologists; Elsevier Science
• Subjects: Abortion, Habitual - blood; Abortion, Habitual - enzymology; Abortion, Habitual - genetics; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Diseases of mother, fetus and pregnancy; European Continental Ancestry Group - genetics; Female; Gene Frequency; Genotype; Gynecology. Andrology. Obstetrics; Heterozygote; Homocysteine - blood; Humans; Medical sciences; Methylenetetrahydrofolate Dehydrogenase (NADP) - blood; Methylenetetrahydrofolate Dehydrogenase (NADP) - genetics; Middle Aged; Polymorphism, Genetic - genetics; Pregnancy; Pregnancy. Fetus. Placenta; Human; Methylenetetrahydrofolate reductase (NADPH); Pregnancy disorders; Enzyme; Pathogenesis; Idiopathic; Habitual abortion; Gene; Cytogenetics; Female; Hyperhomocysteinemia; Oxidoreductases; Molecular biology; Polymorphism

OBJECTIVE: To investigate the association between the C677T polymorphism of the 5,10-methylenetetrahydrofolate reductase gene ( MTHFR), serum homocysteine levels, and idiopathic recurrent miscarriage in a Middle-European white population. METHODS: In a case control study, we investigated 133 women w...