Long-term neurodevelopmental outcome and brain volume after treatment for hydrops fetalis by in utero intravascular transfusion

• Published in: American journal of obstetrics and gynecology Vol. 195; no. 1; pp. 192 - 200
• Main Authors: Harper, Dennis C., Swingle, Hanes M., Weiner, Carl P., Bonthius, Daniel J., Aylward, Glen P., Widness, John A.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Mosby, Inc 01.07.2006; Elsevier
• Subjects: Anemia; Anemias. Hemoglobinopathies; Biological and medical sciences; Blood Transfusion, Intrauterine - methods; Brain - physiopathology; Child; Diseases of mother, fetus and pregnancy; Diseases of red blood cells; Female; Fetus; Follow-Up Studies; Gestational Age; Gynecology. Andrology. Obstetrics; Hematocrit; Hematologic and hematopoietic diseases; Hemolytic disease; Humans; Hydrops; Hydrops Fetalis - mortality; Hydrops Fetalis - physiopathology; Hydrops Fetalis - therapy; Intrauterine blood transfusion; Medical sciences; Neuropsychological Tests; Pregnancy; Pregnancy Outcome; Pregnancy. Fetus. Placenta; Intrauterine blood transfusion; Fetus; Hydrops; Hemolytic disease; Anemia; Psychomotor development; Transfusion; Pregnancy disorders; Gynecology; Central nervous system; Hemopathy; In utero; Long term; Obstetrics; Blood; Encephalon; Fetal diseases; Hemolytic anemia; Hydrops fetalis; Volume; Blood vessel; Circulatory system; Fetal therapy
• ISSN: 0002-9378; 1097-6868; 1097-6868
• DOI: 10.1016/j.ajog.2005.12.012

We tested the hypothesis that long-term neurodevelopmental outcomes of successfully treated fetuses with immune hydrops are similar to their unaffected siblings according to a protocol that addresses the underlying pathophysiologic condition. Sixteen of 18 consecutive hydropic fetuses (89%) who were...