Immunophenotypic characterization, multi-lineage differentiation and aging of zebrafish heart and liver tissue-derived mesenchymal stem cells as a novel approach in stem cell-based therapy

• Published in: Tissue & cell Vol. 57; pp. 15 - 21
• Main Authors: Fathi, Ezzatollah, Farahzadi, Raheleh, Sheikhzadeh, Najmeh
• Format: Journal Article
• Language: English
• Published: Scotland Elsevier Ltd 01.04.2019; Elsevier Science Ltd
• Subjects: Aging; Aging - physiology; Alizarin; Animals; Biocompatibility; Biomarkers; Biomedical materials; CD34 antigen; CD44 antigen; CD90 antigen; Cell Differentiation - physiology; Cell Lineage - physiology; Cell proliferation; Cell Proliferation - physiology; Cell surface; Characterization; Chondrocytes; Chondrogenesis; Cytometry; Danio rerio; Differentiation; Galactosidase; Gene expression; Heart; Hepatocytes; Immunophenotyping; Liver; Liver - cytology; Mesenchymal stem cells; Mesenchymal Stem Cells - cytology; Mesenchyme; Morphology; Multi-lineage differentiation; Myocardium - cytology; Oct-4 protein; Physical characteristics; Pluripotency; Polymerase chain reaction; Regenerative Medicine; Stem cells; Surface markers; Tissues; Toluidine; Toluidine blue; Western blotting; Zebrafish; Zebrafish heart and liver tissue-derived MSCs; β-Galactosidase; Characterization; Regenerative medicine; Zebrafish heart and liver tissue-derived MSCs; Multi-lineage differentiation

[Display omitted] •In this study, isolation and cell surface markers identification of zebrafish heart and liver tissue-derived MSCs were reported for the first time.•Zebrafish heart and liver tissue-derived MSCs exhibited typical MSC characteristics.•These characterizations including multi-potency...