Smokers Have Reduced Nitric Oxide Production by Conducting Airways but Normal Levels in the Alveoli

Air exhaled by cigarette smokers contains reduced amounts of nitric oxide (NO). Measurement of NO at different expiratory flow rates permits calculation of NO production by the conducting airways (VawNO) and alveolar concentration of NO (PALV). An independent measurement of diffusing capacity of the...

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Published inInhalation toxicology Vol. 19; no. 6-7; pp. 533 - 541
Main Authors Pietropaoli, Anthony P., Perillo, Irene B., Perkins, Peter T., Frasier, Lauren M., Speers, Donna M., Frampton, Mark W., Utell, Mark J., Hyde, Richard W.
Format Journal Article
LanguageEnglish
Published England Informa UK Ltd 01.01.2007
Taylor & Francis
Subjects
Adult
Bronchi - metabolism
Exhalation - physiology
Female
Forced Expiratory Flow Rates - physiology
Humans
Male
Middle Aged
Nitric Oxide - biosynthesis
Pulmonary Alveoli - metabolism
Smoking - metabolism
Total Lung Capacity - physiology
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Abstract Air exhaled by cigarette smokers contains reduced amounts of nitric oxide (NO). Measurement of NO at different expiratory flow rates permits calculation of NO production by the conducting airways (VawNO) and alveolar concentration of NO (PALV). An independent measurement of diffusing capacity of the alveolar compartment (DLNO) multiplied by PALV allows calculation of NO production by the alveoli (VLNO). Twelve asymptomatic cigarette smokers and 22 age-matched nonsmokers had measurements of DLNO and expired NO at constant expiratory flow rates varying from 60 to 1500 ml/s. VawNO in smokers was only 22 ± 11 nl/min (mean ± standard deviation, SD) compared to 70 ± 37 nl/min in nonsmokers (p < .0001). In contrast, VLNO showed no significant difference (smokers: 203 ± 104 nl/min, nonsmokers: 209 ± 74 nl/min, p = .86). These data show that the diminished NO expired by smokers results from diminished NO production by the tissues of the conducting airways but normal values produced by the alveoli.
AbstractList Air exhaled by cigarette smokers contains reduced amounts of nitric oxide (NO). Measurement of NO at different expiratory flow rates permits calculation of NO production by the conducting airways (VawNO) and alveolar concentration of NO (PALV). An independent measurement of diffusing capacity of the alveolar compartment (DLNO) multiplied by PALV allows calculation of NO production by the alveoli (VLNO). Twelve asymptomatic cigarette smokers and 22 age-matched nonsmokers had measurements of DLNO and expired NO at constant expiratory flow rates varying from 60 to 1500 ml/s. VawNO in smokers was only 22 ± 11 nl/min (mean ± standard deviation, SD) compared to 70 ± 37 nl/min in nonsmokers (p < .0001). In contrast, VLNO showed no significant difference (smokers: 203 ± 104 nl/min, nonsmokers: 209 ± 74 nl/min, p = .86). These data show that the diminished NO expired by smokers results from diminished NO production by the tissues of the conducting airways but normal values produced by the alveoli.
Air exhaled by cigarette smokers contains reduced amounts of nitric oxide (NO). Measurement of NO at different expiratory flow rates permits calculation of NO production by the conducting airways (Vaw NO ) and alveolar concentration of NO (P ALV ). An independent measurement of diffusing capacity of the alveolar compartment (D LNO ) multiplied by P ALV allows calculation of NO production by the alveoli (V LNO ). Twelve asymptomatic cigarette smokers and 22 age-matched nonsmokers had measurements of D LNO and expired NO at constant expiratory flow rates varying from 60 to 1500 ml/s. Vaw NO in smokers was only 22 ± 11 nl/min (mean ± standard deviation, SD) compared to 70 ± 37 nl/min in nonsmokers (p < .0001). In contrast, V LNO showed no significant difference (smokers: 203 ± 104 nl/min, nonsmokers: 209 ± 74 nl/min, p = .86). These data show that the diminished NO expired by smokers results from diminished NO production by the tissues of the conducting airways but normal values produced by the alveoli.
Air exhaled by cigarette smokers contains reduced amounts of nitric oxide (NO). Measurement of NO at different expiratory flow rates permits calculation of NO production by the conducting airways (Vaw(NO)) and alveolar concentration of NO (P(ALV)). An independent measurement of diffusing capacity of the alveolar compartment (D(LNO)) multiplied by P(ALV) allows calculation of NO production by the alveoli (V(LNO)). Twelve asymptomatic cigarette smokers and 22 age-matched nonsmokers had measurements of D(LNO) and expired NO at constant expiratory flow rates varying from 60 to 1500 ml/s. Vaw(NO) in smokers was only 22 +/- 11 nl/min (mean +/- standard deviation, SD) compared to 70 +/- 37 nl/min in nonsmokers (p < .0001). In contrast, V(LNO) showed no significant difference (smokers: 203 +/- 104 nl/min, nonsmokers: 209 +/- 74 nl/min, p = .86). These data show that the diminished NO expired by smokers results from diminished NO production by the tissues of the conducting airways but normal values produced by the alveoli.
Author Perillo, Irene B.
Perkins, Peter T.
Frampton, Mark W.
Pietropaoli, Anthony P.
Speers, Donna M.
Utell, Mark J.
Hyde, Richard W.
Frasier, Lauren M.
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Cites_doi 10.1053/rmed.2001.1204
10.1152/jappl.1969.27.6.826
10.1152/jappl.1999.87.4.1532
10.1164/ajrccm/143.6.1267
10.1164/ajrccm.164.4.2101023
10.1016/0092-8674(92)90301-R
10.1016/S0034-5687(98)00033-4
10.1183/09031936.04.00125304
10.1056/NEJM199505043321804
10.1152/japplphysiol.00129.2002
10.1164/ajrccm.163.7.2010171
10.1164/ajrccm/143.1.144
10.1164/ajrccm.160.6.ats8-99
10.1161/01.RES.73.5.808
10.1021/bi00144a001
10.1152/japplphysiol.00950.2003
10.1007/978-3-642-87553-3
10.1183/09031936.97.10071683
10.1016/S0140-6736(94)90935-0
10.1165/ajrcmb.26.1.f224
10.1164/rccm.2104003
10.1152/jappl.1998.85.2.653
10.1152/jappl.1997.82.4.1290
10.1164/ajrccm.152.2.7543345
10.1034/j.1399-3003.2000.016003555.x
10.1073/pnas.92.17.7809
10.1097/00000658-198103000-00008
10.1152/japplphysiol.01002.2004
10.1152/jappl.2001.91.5.1931
10.1152/japplphysiol.00044.2002
10.1042/cs1030015
10.1111/j.1476-5381.1993.tb12886.x
10.1152/jappl.1990.68.6.2344
10.1152/japplphysiol.01297.2003
10.1093/ije/16.1.31
10.1046/j.1365-201X.1997.00101.x
10.1164/ajrccm.161.4.9903111
10.2105/AJPH.77.11.1435
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References Pietropaoli A. P. (CIT0028) 1999; 87
Cosio M. G. (CIT0009) 1980; 122
Högman M. (CIT0013) 2002; 103
CIT0031
George S. C. (CIT0011) 2004; 96
Perillo I. B. (CIT0026) 2001; 91
Weibel E. R (CIT0042) 1963
Smith T. C. (CIT0038) 1969; 27
Silkoff P. E. (CIT0034) 2000; 161
Van Muylem A. (CIT0041) 2002; 94
Kharitonov S. (CIT0019) 1997; 10
Jorres R. A (CIT0018) 2000; 16
Adesina A. M. (CIT0001) 1990; 143
Barberà J. A. (CIT0005) 2001; 164
Pitt B. R. (CIT0029) 2002; 26
Tockman M. (CIT0039) 1976; 114
Assrevy J. (CIT0004) 1993; 108
Högman M. (CIT0015) 1997; 159
American Thoracic Society (CIT0002) 1999; 160
Jarvis M. J. (CIT0017) 1987; 77
Shin H.-W. (CIT0035) 2005; 98
Silkoff P. E. (CIT0033) 1998; 113
Morrow J. D. (CIT0025) 1995; 32
Shin H.-W. (CIT0036) 2004; 97
Guo F. H. (CIT0012) 1995; 93
Högman M. (CIT0014) 2002; 96
Buga G. M. (CIT0008) 1993; 78
CIT0023
Rengassamy A. (CIT0030) 1994; 44
Girgis R. E. (CIT0010) 2002; 165
Meyer M. (CIT0024) 1990; 68
Tsoukias N. M. (CIT0040) 1998; 85
White K. A. (CIT0043) 1992; 31
Lowenstein C. J. (CIT0021) 1992; 70
Roughton F. J. W (CIT0032) 1964
Ludwig P. W. (CIT0022) 1982; 126
CIT0003
Persson M. G. (CIT0027) 1994; 343
CIT0007
Kharitonov S. A. (CIT0020) 1995; 152
Shin H.-W. (CIT0037) 2002; 93
Borland C. (CIT0006) 1987; 16
Hyde R. W. (CIT0016) 1997; 82
References_xml – volume: 96
  start-page: 24
  year: 2002
  ident: CIT0014
  publication-title: Respir. Med.
  doi: 10.1053/rmed.2001.1204
  contributor:
    fullname: Högman M.
– volume: 126
  start-page: 977
  year: 1982
  ident: CIT0022
  publication-title: Am. Rev. Respir. Dis.
  contributor:
    fullname: Ludwig P. W.
– volume: 27
  start-page: 826
  year: 1969
  ident: CIT0038
  publication-title: J. Appl. Physiol.
  doi: 10.1152/jappl.1969.27.6.826
  contributor:
    fullname: Smith T. C.
– volume: 87
  start-page: 1532
  year: 1999
  ident: CIT0028
  publication-title: J. Appl. Physiol.
  doi: 10.1152/jappl.1999.87.4.1532
  contributor:
    fullname: Pietropaoli A. P.
– ident: CIT0031
  doi: 10.1164/ajrccm/143.6.1267
– volume: 164
  start-page: 709
  year: 2001
  ident: CIT0005
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/ajrccm.164.4.2101023
  contributor:
    fullname: Barberà J. A.
– volume: 114
  start-page: 711
  year: 1976
  ident: CIT0039
  publication-title: Am. Rev. Respir. Dis.
  contributor:
    fullname: Tockman M.
– start-page: 767
  volume-title: Handbook of physiology, Section 3: Respiration
  year: 1964
  ident: CIT0032
  contributor:
    fullname: Roughton F. J. W
– volume: 44
  start-page: 124
  year: 1994
  ident: CIT0030
  publication-title: Mol. Pharmacol.
  contributor:
    fullname: Rengassamy A.
– volume: 70
  start-page: 705
  year: 1992
  ident: CIT0021
  publication-title: Cell
  doi: 10.1016/0092-8674(92)90301-R
  contributor:
    fullname: Lowenstein C. J.
– volume: 113
  start-page: 33
  year: 1998
  ident: CIT0033
  publication-title: Respir. Physiol.
  doi: 10.1016/S0034-5687(98)00033-4
  contributor:
    fullname: Silkoff P. E.
– ident: CIT0007
  doi: 10.1183/09031936.04.00125304
– volume: 32
  start-page: 1198
  year: 1995
  ident: CIT0025
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM199505043321804
  contributor:
    fullname: Morrow J. D.
– volume: 93
  start-page: 2070
  year: 2002
  ident: CIT0037
  publication-title: J. Appl. Physiol.
  doi: 10.1152/japplphysiol.00129.2002
  contributor:
    fullname: Shin H.-W.
– ident: CIT0023
  doi: 10.1164/ajrccm.163.7.2010171
– volume: 143
  start-page: 144
  year: 1990
  ident: CIT0001
  publication-title: Am. Rev. Respir. Dis.
  doi: 10.1164/ajrccm/143.1.144
  contributor:
    fullname: Adesina A. M.
– volume: 122
  start-page: 265
  year: 1980
  ident: CIT0009
  publication-title: Am. Rev. Respir. Dis.
  contributor:
    fullname: Cosio M. G.
– volume: 160
  start-page: 2104
  year: 1999
  ident: CIT0002
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/ajrccm.160.6.ats8-99
  contributor:
    fullname: American Thoracic Society
– volume: 78
  start-page: 808
  year: 1993
  ident: CIT0008
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.73.5.808
  contributor:
    fullname: Buga G. M.
– volume: 31
  start-page: 6627
  year: 1992
  ident: CIT0043
  publication-title: Biochemistry
  doi: 10.1021/bi00144a001
  contributor:
    fullname: White K. A.
– volume: 96
  start-page: 831
  year: 2004
  ident: CIT0011
  publication-title: J. Appl. Physiol.
  doi: 10.1152/japplphysiol.00950.2003
  contributor:
    fullname: George S. C.
– volume-title: Morphometrics of the human lung
  year: 1963
  ident: CIT0042
  doi: 10.1007/978-3-642-87553-3
  contributor:
    fullname: Weibel E. R
– volume: 10
  start-page: 1683
  year: 1997
  ident: CIT0019
  publication-title: Eur. Respir. J.
  doi: 10.1183/09031936.97.10071683
  contributor:
    fullname: Kharitonov S.
– volume: 343
  start-page: 146
  year: 1994
  ident: CIT0027
  publication-title: Lancet
  doi: 10.1016/S0140-6736(94)90935-0
  contributor:
    fullname: Persson M. G.
– volume: 26
  start-page: 6
  year: 2002
  ident: CIT0029
  publication-title: Am. J. Respir. Cell. Mol. Biol.
  doi: 10.1165/ajrcmb.26.1.f224
  contributor:
    fullname: Pitt B. R.
– volume: 165
  start-page: 1587
  year: 2002
  ident: CIT0010
  publication-title: Am. Rev. Respir. Crit. Care Med.
  doi: 10.1164/rccm.2104003
  contributor:
    fullname: Girgis R. E.
– volume: 85
  start-page: 653
  year: 1998
  ident: CIT0040
  publication-title: J. Appl. Physiol.
  doi: 10.1152/jappl.1998.85.2.653
  contributor:
    fullname: Tsoukias N. M.
– volume: 82
  start-page: 1290
  year: 1997
  ident: CIT0016
  publication-title: J. Appl. Physiol.
  doi: 10.1152/jappl.1997.82.4.1290
  contributor:
    fullname: Hyde R. W.
– volume: 152
  start-page: 609
  year: 1995
  ident: CIT0020
  publication-title: Am. J. Resp. Crit. Care Med.
  doi: 10.1164/ajrccm.152.2.7543345
  contributor:
    fullname: Kharitonov S. A.
– volume: 16
  start-page: 555
  year: 2000
  ident: CIT0018
  publication-title: Eur. Respir. J.
  doi: 10.1034/j.1399-3003.2000.016003555.x
  contributor:
    fullname: Jorres R. A
– volume: 93
  start-page: 7809
  year: 1995
  ident: CIT0012
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.92.17.7809
  contributor:
    fullname: Guo F. H.
– ident: CIT0003
  doi: 10.1097/00000658-198103000-00008
– volume: 98
  start-page: 1869
  year: 2005
  ident: CIT0035
  publication-title: J. Appl. Physiol.
  doi: 10.1152/japplphysiol.01002.2004
  contributor:
    fullname: Shin H.-W.
– volume: 91
  start-page: 1931
  year: 2001
  ident: CIT0026
  publication-title: J. Appl. Physiol.
  doi: 10.1152/jappl.2001.91.5.1931
  contributor:
    fullname: Perillo I. B.
– volume: 94
  start-page: 119
  year: 2002
  ident: CIT0041
  publication-title: J. Appl. Phyiol.
  doi: 10.1152/japplphysiol.00044.2002
  contributor:
    fullname: Van Muylem A.
– volume: 103
  start-page: 15
  year: 2002
  ident: CIT0013
  publication-title: Clin. Sci.
  doi: 10.1042/cs1030015
  contributor:
    fullname: Högman M.
– volume: 108
  start-page: 833
  year: 1993
  ident: CIT0004
  publication-title: Br. J. Pharmacol.
  doi: 10.1111/j.1476-5381.1993.tb12886.x
  contributor:
    fullname: Assrevy J.
– volume: 68
  start-page: 2344
  year: 1990
  ident: CIT0024
  publication-title: J. Appl. Physiol.
  doi: 10.1152/jappl.1990.68.6.2344
  contributor:
    fullname: Meyer M.
– volume: 97
  start-page: 874
  year: 2004
  ident: CIT0036
  publication-title: J. Appl. Physiol.
  doi: 10.1152/japplphysiol.01297.2003
  contributor:
    fullname: Shin H.-W.
– volume: 16
  start-page: 31
  year: 1987
  ident: CIT0006
  publication-title: Int. J. Epidemiol.
  doi: 10.1093/ije/16.1.31
  contributor:
    fullname: Borland C.
– volume: 159
  start-page: 345
  year: 1997
  ident: CIT0015
  publication-title: Acta Physiol. Scand.
  doi: 10.1046/j.1365-201X.1997.00101.x
  contributor:
    fullname: Högman M.
– volume: 161
  start-page: 1218
  year: 2000
  ident: CIT0034
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/ajrccm.161.4.9903111
  contributor:
    fullname: Silkoff P. E.
– volume: 77
  start-page: 1435
  year: 1987
  ident: CIT0017
  publication-title: Am. J. Public Health
  doi: 10.2105/AJPH.77.11.1435
  contributor:
    fullname: Jarvis M. J.
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Snippet Air exhaled by cigarette smokers contains reduced amounts of nitric oxide (NO). Measurement of NO at different expiratory flow rates permits calculation of NO...
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SubjectTerms Adult
Bronchi - metabolism
Exhalation - physiology
Female
Forced Expiratory Flow Rates - physiology
Humans
Male
Middle Aged
Nitric Oxide - biosynthesis
Pulmonary Alveoli - metabolism
Smoking - metabolism
Total Lung Capacity - physiology
Title Smokers Have Reduced Nitric Oxide Production by Conducting Airways but Normal Levels in the Alveoli
URI https://www.tandfonline.com/doi/abs/10.1080/08958370701260673
https://www.ncbi.nlm.nih.gov/pubmed/17497531
https://search.proquest.com/docview/20532852
https://search.proquest.com/docview/70501105
Volume 19
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