Elucidating the Role of Dose in the Biopharmaceutics Classification of Drugs: The Concepts of Critical Dose, Effective In Vivo Solubility, and Dose-Dependent BCS - Charkoftaki, Georgia; Dokoumetzidis, Aristides; Valsami, Georgia; Macheras, Panos (Pharmaceutical research, 2012)
Keywords: Aqueous solutions; Biochemistry; Biological and medical sciences; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Biopharmaceutics - methods; Classification; Dose-Response Relationship, Drug; Drug delivery systems; Efficiency; General pharmacology; Intestinal Absorption; Medical Law; Medical sciences; Models, Biological; Permeability; Pharmaceutical Preparations - administration & dosage; Pharmaceutical Preparations - chemistry; Pharmaceutical Preparations - classification; Pharmaceutical sciences; Pharmaceutical technology. Pharmaceutical industry; Pharmacokinetics; Pharmacology. Drug treatments; Pharmacology/Toxicology; Pharmacy; Research Paper; Solubility; effective; solubility; dose; BCS; DDBCS; critical dose; Drug; effective in vivo solubility; Pharmaceutical technology; Solubility; Biopharmaceutics; In vivo; Classification; Effective dose; Physicochemical properties