Seizure Frequencies and Number of Anti-epileptic Drugs as Risk Factors for Sudden Unexpected Death in Epilepsy

The purpose of this study was to investigate the association between clinical variables and sudden unexpected death in epilepsy (SUDEP) and identify risk factors for SUDEP. SUDEP is one of the most frequent causes of death in patients with epilepsy. Previous studies have reported possible risk facto...

Full description

Saved in:
Bibliographic Details
Published inJournal of Korean medical science Vol. 30; no. 6; pp. 788 - 792
Main Authors Ryu, Han Uk, Hong, Jin Pyo, Han, Su-Hyun, Choi, Eun Ju, Song, Ji Hyun, Lee, Sang-Ahm, Kang, Joong Koo
Format Journal Article
LanguageEnglish
Published Korea (South) The Korean Academy of Medical Sciences 01.06.2015
대한의학회
Subjects
Adult
Age Distribution
Anticonvulsants - therapeutic use
Death, Sudden - epidemiology
Death, Sudden - prevention & control
Epilepsy - mortality
Epilepsy - prevention & control
Female
Humans
Incidence
Male
Original
Recurrence
Republic of Korea - epidemiology
Risk Factors
Sex Distribution
Survival Rate
Young Adult
의학일반
Republic of Korea
Sudden Unexpected Death in Epilepsy
Polytherapy
Risk Factors
Online AccessGet full text

Cover

Abstract The purpose of this study was to investigate the association between clinical variables and sudden unexpected death in epilepsy (SUDEP) and identify risk factors for SUDEP. SUDEP is one of the most frequent causes of death in patients with epilepsy. Previous studies have reported possible risk factors associated with SUDEP, but there need to be elucidated yet. The cases were 26 patients with SUDEP and three control patients were included for each case, matched for age, sex, and date of initial clinical visit. All demographic and clinical characteristics, including age, sex, disease duration, classification of epilepsy, age at seizure onset, kind and number of antiepileptic drugs, were compared between cases and controls. Seizure frequency was higher in SUDEP cases than in controls (P=0.035). Univariate analysis using conditional logistic regression showed that higher seizure frequency (odds ratio [OR]=3.1, P=0.021) and the number of antiepileptic drugs (AEDs) (OR=2.0, P=0.009) were significantly associated with SUDEP. Only the number of AEDs remained significant in multivariate analysis (OR=1.8, P=0.026). Frequent seizures and multi-drug therapy were associated with SUDEP. This may suggest that the severity of epilepsy is associated with SUDEP, regardless of the type of AED used.
AbstractList The purpose of this study was to investigate the association between clinical variables and sudden unexpected death in epilepsy (SUDEP) and identify risk factors for SUDEP. SUDEP is one of the most frequent causes of death in patients with epilepsy. Previous studies have reported possible risk factors associated with SUDEP, but there need to be elucidated yet. The cases were 26 patients with SUDEP and three control patients were included for each case, matched for age, sex, and date of initial clinical visit. All demographic and clinical characteristics, including age, sex, disease duration, classification of epilepsy, age at seizure onset, kind and number of antiepileptic drugs, were compared between cases and controls. Seizure frequency was higher in SUDEP cases than in controls ( P =0.035). Univariate analysis using conditional logistic regression showed that higher seizure frequency (odds ratio [OR]=3.1, P =0.021) and the number of antiepileptic drugs (AEDs) (OR=2.0, P =0.009) were significantly associated with SUDEP. Only the number of AEDs remained significant in multivariate analysis (OR=1.8, P =0.026). Frequent seizures and multi-drug therapy were associated with SUDEP. This may suggest that the severity of epilepsy is associated with SUDEP, regardless of the type of AED used.
The purpose of this study was to investigate the association between clinical variables and sudden unexpected death in epilepsy (SUDEP) and identify risk factors for SUDEP. SUDEP is one of the most frequent causes of death in patients with epilepsy. Previous studies have reported possible risk factors associated with SUDEP, but there need to be elucidated yet. The cases were 26 patients with SUDEP and three control patients were included for each case, matched for age, sex, and date of initial clinical visit. All demographic and clinical characteristics, including age, sex, disease duration, classification of epilepsy, age at seizure onset, kind and number of antiepileptic drugs, were compared between cases and controls. Seizure frequency was higher in SUDEP cases than in controls (P=0.035). Univariate analysis using conditional logistic regression showed that higher seizure frequency (odds ratio [OR]=3.1, P=0.021) and the number of antiepileptic drugs (AEDs) (OR=2.0, P=0.009) were significantly associated with SUDEP. Only the number of AEDs remained significant in multivariate analysis (OR=1.8, P=0.026). Frequent seizures and multi-drug therapy were associated with SUDEP. This may suggest that the severity of epilepsy is associated with SUDEP, regardless of the type of AED used.The purpose of this study was to investigate the association between clinical variables and sudden unexpected death in epilepsy (SUDEP) and identify risk factors for SUDEP. SUDEP is one of the most frequent causes of death in patients with epilepsy. Previous studies have reported possible risk factors associated with SUDEP, but there need to be elucidated yet. The cases were 26 patients with SUDEP and three control patients were included for each case, matched for age, sex, and date of initial clinical visit. All demographic and clinical characteristics, including age, sex, disease duration, classification of epilepsy, age at seizure onset, kind and number of antiepileptic drugs, were compared between cases and controls. Seizure frequency was higher in SUDEP cases than in controls (P=0.035). Univariate analysis using conditional logistic regression showed that higher seizure frequency (odds ratio [OR]=3.1, P=0.021) and the number of antiepileptic drugs (AEDs) (OR=2.0, P=0.009) were significantly associated with SUDEP. Only the number of AEDs remained significant in multivariate analysis (OR=1.8, P=0.026). Frequent seizures and multi-drug therapy were associated with SUDEP. This may suggest that the severity of epilepsy is associated with SUDEP, regardless of the type of AED used.
The purpose of this study was to investigate the association between clinical variables and sudden unexpected death in epilepsy (SUDEP) and identify risk factors for SUDEP. SUDEP is one of the most frequent causes of death in patients with epilepsy. Previous studies have reported possible risk factors associated with SUDEP, but there need to be elucidated yet. The cases were 26 patients with SUDEP and three control patients were included for each case, matched for age, sex, and date of initial clinical visit. All demographic and clinical characteristics, including age, sex, disease duration, classification of epilepsy, age at seizure onset, kind and number of antiepileptic drugs, were compared between cases and controls. Seizure frequency was higher in SUDEP cases than in controls (P=0.035). Univariate analysis using conditional logistic regression showed that higher seizure frequency (odds ratio [OR]=3.1, P=0.021) and the number of antiepileptic drugs (AEDs) (OR=2.0, P=0.009) were significantly associated with SUDEP. Only the number of AEDs remained significant in multivariate analysis (OR=1.8, P=0.026). Frequent seizures and multi-drug therapy were associated with SUDEP. This may suggest that the severity of epilepsy is associated with SUDEP, regardless of the type of AED used.
The purpose of this study was to investigate the association between clinical variables and sudden unexpected death in epilepsy (SUDEP) and identify risk factors for SUDEP. SUDEP is one of the most frequent causes of death in patients with epilepsy. Previous studies have reported possible risk factors associated with SUDEP, but there need to be elucidated yet. The cases were 26 patients with SUDEP and three control patients were included for each case, matched for age, sex, and date of initial clinical visit. All demographic and clinical characteristics, including age, sex, disease duration, classification of epilepsy, age at seizure onset, kind and number of antiepileptic drugs, were compared between cases and controls. Seizure frequency was higher in SUDEP cases than in controls (P = 0.035). Univariate analysis using conditional logistic regression showed that higher seizure frequency (odds ratio [OR] = 3.1, P = 0.021) and the number of antiepileptic drugs (AEDs) (OR = 2.0, P = 0.009) were significantly associated with SUDEP. Only the number of AEDs remained significant in multivariate analysis (OR = 1.8, P = 0.026). Frequent seizures and multi-drug therapy were associated with SUDEP. This may suggest that the severity of epilepsy is associated with SUDEP, regardless of the type of AED used. KCI Citation Count: 8
Author Han, Su-Hyun
Hong, Jin Pyo
Lee, Sang-Ahm
Kang, Joong Koo
Song, Ji Hyun
Ryu, Han Uk
Choi, Eun Ju
AuthorAffiliation 2 Department of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
3 Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
1 Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
AuthorAffiliation_xml – name: 2 Department of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
– name: 1 Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
– name: 3 Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
Author_xml – sequence: 1
  givenname: Han Uk
  orcidid: 0000-0001-7147-3735
  surname: Ryu
  fullname: Ryu, Han Uk
  organization: Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
– sequence: 2
  givenname: Jin Pyo
  orcidid: 0000-0001-5384-2605
  surname: Hong
  fullname: Hong, Jin Pyo
  organization: Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
– sequence: 3
  givenname: Su-Hyun
  orcidid: 0000-0002-3084-6985
  surname: Han
  fullname: Han, Su-Hyun
  organization: Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
– sequence: 4
  givenname: Eun Ju
  orcidid: 0000-0002-6804-5972
  surname: Choi
  fullname: Choi, Eun Ju
  organization: Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
– sequence: 5
  givenname: Ji Hyun
  orcidid: 0000-0002-5592-2411
  surname: Song
  fullname: Song, Ji Hyun
  organization: Department of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
– sequence: 6
  givenname: Sang-Ahm
  orcidid: 0000-0002-6743-0545
  surname: Lee
  fullname: Lee, Sang-Ahm
  organization: Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
– sequence: 7
  givenname: Joong Koo
  orcidid: 0000-0003-0941-3824
  surname: Kang
  fullname: Kang, Joong Koo
  organization: Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26028933$$D View this record in MEDLINE/PubMed
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001996297$$DAccess content in National Research Foundation of Korea (NRF)
BookMark eNp9kUtv3CAUhVGVqkmm_QNdVCy7sQvG2HhTaZRkkkhRK-WxRhhfJ2RscAFXTX998UybPhZlc9HlO_ege47RgXUWEHpLSc5YWX143I4hLwjlOSN5lddCvEBHlDciqxivD9KdUJqJhpWH6DiER0IKzgv2Ch0WFSlSnx0hewPm--wBbzx8mcFqAwEr2-FP89iCx67HaxtNBpMZYIpG41M_3yck4GsTtnijdHQ-4N55fDN3HVh8Z-HbBDpCh09BxQdsLD7bycPTa_SyV0OANz_rCt1tzm5PLrKrz-eXJ-urTJeMxwwoEKGhL7hqy4qQjnWt4rzVQJq2q0nNStG0FXDW8h7qRrcN69tG6J6TsugKtkLv93Ot7-VWG-mU2dV7J7derq9vLyWvC1azhH7co9PcjtBpsNGrQU7ejMo_7YR_v1jzkMZ8leVyBP3tNXmXVhiiHE3QMAzKgpuDpJXgdVnTtPAVeven17PJrzwSUOwB7V0IHvpnhBK5hC6X0OUSumREVjKFnkTiH5E2UUXjlv-a4X_SH34HtNs
CitedBy_id crossref_primary_10_1007_s11606_024_08817_4
crossref_primary_10_1016_j_yebeh_2015_11_019
crossref_primary_10_1002_epi4_12722
crossref_primary_10_1007_s40261_018_0677_6
crossref_primary_10_1007_s40263_024_01112_0
crossref_primary_10_1016_j_japh_2017_06_002
crossref_primary_10_1016_j_yebeh_2022_108770
crossref_primary_10_1111_epi_14458
crossref_primary_10_1109_ACCESS_2020_2969055
crossref_primary_10_1109_ACCESS_2020_3028139
crossref_primary_10_1111_jsap_12771
crossref_primary_10_1007_s12024_021_00444_3
crossref_primary_10_1016_j_yebeh_2017_02_002
Cites_doi 10.2165/00002018-200326100-00001
10.1111/j.1528-1167.2011.03360.x
10.1016/j.yebeh.2012.09.021
10.1016/S0140-6736(11)60176-1
10.1111/j.1528-1157.1997.tb06128.x
10.1046/j.1528-1157.2002.40001.x
10.1111/j.1528-1167.2009.02069.x
10.1111/j.1528-1167.2010.02952.x
10.1016/j.eplepsyres.2004.10.002
10.1016/S1059-1311(02)00352-7
10.3988/jcn.2014.10.3.175
10.1111/j.1528-1157.1995.tb01661.x
10.1002/ana.410370416
10.1002/ana.410260203
10.1212/WNL.56.4.519
10.1111/j.1528-1167.2005.00411.x
10.1371/journal.pone.0042749
10.1016/0920-1211(89)90068-5
10.1038/nrneurol.2011.34
10.1136/jnnp.60.3.297
10.1016/S0140-6736(98)05114-9
10.1111/j.1528-1167.2011.03354.x
ContentType Journal Article
Copyright 2015 The Korean Academy of Medical Sciences. 2015
Copyright_xml – notice: 2015 The Korean Academy of Medical Sciences. 2015
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
ACYCR
DOI 10.3346/jkms.2015.30.6.788
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
Korean Citation Index
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1598-6357
EndPage 792
ExternalDocumentID oai_kci_go_kr_ARTI_572373
PMC4444481
26028933
10_3346_jkms_2015_30_6_788
Genre Research Support, Non-U.S. Gov't
Journal Article
Observational Study
GeographicLocations Republic of Korea
GeographicLocations_xml – name: Republic of Korea
GrantInformation_xml – fundername: Ministry of Health and Welfare
  grantid: HI12C0035
GroupedDBID ---
29K
2WC
3O-
5-W
53G
5GY
8JR
8XY
9ZL
AAYXX
ADBBV
ADRAZ
AENEX
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
CITATION
CS3
D-I
DIK
DU5
E3Z
EBS
EF.
EJD
F5P
FRP
GROUPED_DOAJ
GX1
HYE
KQ8
M48
O5R
O5S
OK1
OVT
PGMZT
RNS
RPM
TR2
W2D
XSB
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
08R
ACYCR
M~E
ID FETCH-LOGICAL-c435t-e1e08cef25ab4600d3dba55bce09bd7073489b6e53b5fe79cb93fb98cf5042d23
IEDL.DBID M48
ISSN 1011-8934
1598-6357
IngestDate Tue Nov 21 21:40:42 EST 2023
Thu Aug 21 14:23:33 EDT 2025
Fri Jul 11 10:03:43 EDT 2025
Mon Jul 21 06:02:55 EDT 2025
Tue Jul 01 01:44:55 EDT 2025
Thu Apr 24 23:07:25 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 6
Keywords Sudden Unexpected Death in Epilepsy
Polytherapy
Risk Factors
Language English
License http://creativecommons.org/licenses/by-nc/4.0
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c435t-e1e08cef25ab4600d3dba55bce09bd7073489b6e53b5fe79cb93fb98cf5042d23
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Undefined-3
Han Uk Ryu and Jin Pyo Hong contributed equally to this work.
G704-000345.2015.30.6.015
ORCID 0000-0002-3084-6985
0000-0002-6804-5972
0000-0001-5384-2605
0000-0003-0941-3824
0000-0002-5592-2411
0000-0002-6743-0545
0000-0001-7147-3735
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.3346/jkms.2015.30.6.788
PMID 26028933
PQID 1685747189
PQPubID 23479
PageCount 5
ParticipantIDs nrf_kci_oai_kci_go_kr_ARTI_572373
pubmedcentral_primary_oai_pubmedcentral_nih_gov_4444481
proquest_miscellaneous_1685747189
pubmed_primary_26028933
crossref_primary_10_3346_jkms_2015_30_6_788
crossref_citationtrail_10_3346_jkms_2015_30_6_788
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2015-06-01
PublicationDateYYYYMMDD 2015-06-01
PublicationDate_xml – month: 06
  year: 2015
  text: 2015-06-01
  day: 01
PublicationDecade 2010
PublicationPlace Korea (South)
PublicationPlace_xml – name: Korea (South)
PublicationTitle Journal of Korean medical science
PublicationTitleAlternate J Korean Med Sci
PublicationYear 2015
Publisher The Korean Academy of Medical Sciences
대한의학회
Publisher_xml – name: The Korean Academy of Medical Sciences
– name: 대한의학회
References Walczak (10.3346/jkms.2015.30.6.788_ref17) 2001; 56
Opeskin (10.3346/jkms.2015.30.6.788_ref12) 2003; 12
Hesdorffer (10.3346/jkms.2015.30.6.788_ref8) 2012; 53
Tomson (10.3346/jkms.2015.30.6.788_ref19) 1997; 38
Nilsson (10.3346/jkms.2015.30.6.788_ref11) 1999; 353
Johnston (10.3346/jkms.2015.30.6.788_ref4) 1995; 37
Danielsson (10.3346/jkms.2015.30.6.788_ref21) 2005; 63
Leestma (10.3346/jkms.2015.30.6.788_ref13) 1989; 26
Lamberts (10.3346/jkms.2015.30.6.788_ref9) 2012; 53
Hesdorffer (10.3346/jkms.2015.30.6.788_ref7) 2011; 52
Kwon (10.3346/jkms.2015.30.6.788_ref15) 2014; 10
Bardai (10.3346/jkms.2015.30.6.788_ref5) 2012; 7
Schraeder (10.3346/jkms.2015.30.6.788_ref2) 1989; 3
Beal (10.3346/jkms.2015.30.6.788_ref6) 2011; 7
Saetre (10.3346/jkms.2015.30.6.788_ref20) 2009; 50
Walczak (10.3346/jkms.2015.30.6.788_ref22) 2003; 26
Nashef (10.3346/jkms.2015.30.6.788_ref3) 1996; 60
Feldman (10.3346/jkms.2015.30.6.788_ref18) 2013; 26
Tomson (10.3346/jkms.2015.30.6.788_ref1) 2005; 46
Shorvon (10.3346/jkms.2015.30.6.788_ref14) 2011; 378
Tennis (10.3346/jkms.2015.30.6.788_ref16) 1995; 36
Nilsson (10.3346/jkms.2015.30.6.788_ref10) 2002; 43
8609507 - J Neurol Neurosurg Psychiatry. 1996 Mar;60(3):297-300
25045369 - J Clin Neurol. 2014 Jul;10(3):175-88
2774506 - Ann Neurol. 1989 Aug;26(2):195-203
19400874 - Epilepsia. 2009 Aug;50(8):1841-9
16393182 - Epilepsia. 2005;46 Suppl 11:54-61
12862502 - Drug Saf. 2003;26(10):673-83
10093982 - Lancet. 1999 Mar 13;353(9156):888-93
22916156 - PLoS One. 2012;7(8):e42749
12060025 - Epilepsia. 2002 Jun;43(6):644-51
21468119 - Nat Rev Neurol. 2011 Apr;7(4):188
19909327 - Epilepsia. 1997 Nov;38(11 Suppl):S48-51
12967573 - Seizure. 2003 Oct;12(7):456-64
8001505 - Epilepsia. 1995 Jan;36(1):29-36
21737136 - Lancet. 2011 Dec 10;378(9808):2028-38
21671925 - Epilepsia. 2011 Jun;52(6):1150-9
22192074 - Epilepsia. 2012 Feb;53(2):253-7
15716081 - Epilepsy Res. 2005 Jan;63(1):17-25
23218812 - Epilepsy Behav. 2013 Mar;26(3):421-6
7717690 - Ann Neurol. 1995 Apr;37(4):531-7
22191685 - Epilepsia. 2012 Feb;53(2):249-52
11222798 - Neurology. 2001 Feb 27;56(4):519-25
2645119 - Epilepsy Res. 1989 Jan-Feb;3(1):55-62
References_xml – volume: 26
  start-page: 673
  year: 2003
  ident: 10.3346/jkms.2015.30.6.788_ref22
  publication-title: Drug Saf
  doi: 10.2165/00002018-200326100-00001
– volume: 53
  start-page: 253
  year: 2012
  ident: 10.3346/jkms.2015.30.6.788_ref9
  publication-title: Epilepsia
  doi: 10.1111/j.1528-1167.2011.03360.x
– volume: 26
  start-page: 421
  year: 2013
  ident: 10.3346/jkms.2015.30.6.788_ref18
  publication-title: Epilepsy Behav
  doi: 10.1016/j.yebeh.2012.09.021
– volume: 378
  start-page: 2028
  year: 2011
  ident: 10.3346/jkms.2015.30.6.788_ref14
  publication-title: Lancet
  doi: 10.1016/S0140-6736(11)60176-1
– volume: 38
  start-page: S48
  year: 1997
  ident: 10.3346/jkms.2015.30.6.788_ref19
  publication-title: Epilepsia
  doi: 10.1111/j.1528-1157.1997.tb06128.x
– volume: 43
  start-page: 644
  year: 2002
  ident: 10.3346/jkms.2015.30.6.788_ref10
  publication-title: Epilepsia
  doi: 10.1046/j.1528-1157.2002.40001.x
– volume: 50
  start-page: 1841
  year: 2009
  ident: 10.3346/jkms.2015.30.6.788_ref20
  publication-title: Epilepsia
  doi: 10.1111/j.1528-1167.2009.02069.x
– volume: 52
  start-page: 1150
  year: 2011
  ident: 10.3346/jkms.2015.30.6.788_ref7
  publication-title: Epilepsia
  doi: 10.1111/j.1528-1167.2010.02952.x
– volume: 63
  start-page: 17
  year: 2005
  ident: 10.3346/jkms.2015.30.6.788_ref21
  publication-title: Epilepsy Res
  doi: 10.1016/j.eplepsyres.2004.10.002
– volume: 12
  start-page: 456
  year: 2003
  ident: 10.3346/jkms.2015.30.6.788_ref12
  publication-title: Seizure
  doi: 10.1016/S1059-1311(02)00352-7
– volume: 10
  start-page: 175
  year: 2014
  ident: 10.3346/jkms.2015.30.6.788_ref15
  publication-title: J Clin Neurol
  doi: 10.3988/jcn.2014.10.3.175
– volume: 36
  start-page: 29
  year: 1995
  ident: 10.3346/jkms.2015.30.6.788_ref16
  publication-title: Epilepsia
  doi: 10.1111/j.1528-1157.1995.tb01661.x
– volume: 37
  start-page: 531
  year: 1995
  ident: 10.3346/jkms.2015.30.6.788_ref4
  publication-title: Ann Neurol
  doi: 10.1002/ana.410370416
– volume: 26
  start-page: 195
  year: 1989
  ident: 10.3346/jkms.2015.30.6.788_ref13
  publication-title: Ann Neurol
  doi: 10.1002/ana.410260203
– volume: 56
  start-page: 519
  year: 2001
  ident: 10.3346/jkms.2015.30.6.788_ref17
  publication-title: Neurology
  doi: 10.1212/WNL.56.4.519
– volume: 46
  start-page: 54
  year: 2005
  ident: 10.3346/jkms.2015.30.6.788_ref1
  publication-title: Epilepsia
  doi: 10.1111/j.1528-1167.2005.00411.x
– volume: 7
  start-page: e42749
  year: 2012
  ident: 10.3346/jkms.2015.30.6.788_ref5
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0042749
– volume: 3
  start-page: 55
  year: 1989
  ident: 10.3346/jkms.2015.30.6.788_ref2
  publication-title: Epilepsy Res
  doi: 10.1016/0920-1211(89)90068-5
– volume: 7
  start-page: 188
  year: 2011
  ident: 10.3346/jkms.2015.30.6.788_ref6
  publication-title: Nat Rev Neurol
  doi: 10.1038/nrneurol.2011.34
– volume: 60
  start-page: 297
  year: 1996
  ident: 10.3346/jkms.2015.30.6.788_ref3
  publication-title: J Neurol Neurosurg Psychiatry
  doi: 10.1136/jnnp.60.3.297
– volume: 353
  start-page: 888
  year: 1999
  ident: 10.3346/jkms.2015.30.6.788_ref11
  publication-title: Lancet
  doi: 10.1016/S0140-6736(98)05114-9
– volume: 53
  start-page: 249
  year: 2012
  ident: 10.3346/jkms.2015.30.6.788_ref8
  publication-title: Epilepsia
  doi: 10.1111/j.1528-1167.2011.03354.x
– reference: 2774506 - Ann Neurol. 1989 Aug;26(2):195-203
– reference: 25045369 - J Clin Neurol. 2014 Jul;10(3):175-88
– reference: 22191685 - Epilepsia. 2012 Feb;53(2):249-52
– reference: 22192074 - Epilepsia. 2012 Feb;53(2):253-7
– reference: 21737136 - Lancet. 2011 Dec 10;378(9808):2028-38
– reference: 8001505 - Epilepsia. 1995 Jan;36(1):29-36
– reference: 12862502 - Drug Saf. 2003;26(10):673-83
– reference: 8609507 - J Neurol Neurosurg Psychiatry. 1996 Mar;60(3):297-300
– reference: 11222798 - Neurology. 2001 Feb 27;56(4):519-25
– reference: 19400874 - Epilepsia. 2009 Aug;50(8):1841-9
– reference: 21671925 - Epilepsia. 2011 Jun;52(6):1150-9
– reference: 15716081 - Epilepsy Res. 2005 Jan;63(1):17-25
– reference: 19909327 - Epilepsia. 1997 Nov;38(11 Suppl):S48-51
– reference: 12967573 - Seizure. 2003 Oct;12(7):456-64
– reference: 21468119 - Nat Rev Neurol. 2011 Apr;7(4):188
– reference: 12060025 - Epilepsia. 2002 Jun;43(6):644-51
– reference: 16393182 - Epilepsia. 2005;46 Suppl 11:54-61
– reference: 10093982 - Lancet. 1999 Mar 13;353(9156):888-93
– reference: 7717690 - Ann Neurol. 1995 Apr;37(4):531-7
– reference: 23218812 - Epilepsy Behav. 2013 Mar;26(3):421-6
– reference: 22916156 - PLoS One. 2012;7(8):e42749
– reference: 2645119 - Epilepsy Res. 1989 Jan-Feb;3(1):55-62
SSID ssj0025523
Score 2.138736
Snippet The purpose of this study was to investigate the association between clinical variables and sudden unexpected death in epilepsy (SUDEP) and identify risk...
SourceID nrf
pubmedcentral
proquest
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 788
SubjectTerms Adult
Age Distribution
Anticonvulsants - therapeutic use
Death, Sudden - epidemiology
Death, Sudden - prevention & control
Epilepsy - mortality
Epilepsy - prevention & control
Female
Humans
Incidence
Male
Original
Recurrence
Republic of Korea - epidemiology
Risk Factors
Sex Distribution
Survival Rate
Young Adult
의학일반
Title Seizure Frequencies and Number of Anti-epileptic Drugs as Risk Factors for Sudden Unexpected Death in Epilepsy
URI https://www.ncbi.nlm.nih.gov/pubmed/26028933
https://www.proquest.com/docview/1685747189
https://pubmed.ncbi.nlm.nih.gov/PMC4444481
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001996297
Volume 30
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
ispartofPNX Journal of Korean Medical Science, 2015, 30(6), 201, pp.788-792
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELbaIiEuiPJcSldG4oaySmI7jg8VqmhXLag9UFbqzYofaaMt3pJsJMqvZybJrlhUELn4kHGseDye78s4M4S845mT4PZ4VFiTRtzxMlLCicipMmesSK10XbbP8-xkxj9disstsip3NExgcy-1w3pSs_pm8uP73Qcw-ANknAwjlPNvmHg7ERMWT7IJkLpt8gA8k0RDPePrqAKg567cG3jwPMI8bP1PNH95xoaj2g51eR8G_fMo5W--afqEPB5AJT3sV8Eu2fLhKXl4NoTNn5Fw4aufbe3ptO5PTgM9pkVw9LyrB0IXJT0Myyryt7BHwB5i6VHdXoFIQ79UzZxO-6I8FAAuvWhxq6KzgLUBLOBVeoQoklaBHnfdm7vnZDY9_vrxJBoKLUQW0NIy8omPc-vLVBSGAwJyzJlCCGN9rIyTMWbAUSbzghlReqmsUaw0KrelAJt3KXtBdsIi-FeEFtw7kycwIbHhSpYqZ4WXQHIstCJxI5KsZlXbIQs5FsO40cBGUBMaNaFRE5rFOtOgiRF5v-5z2-fg-Kf0W1CWnttKY-psbK8Wel5rIAinWsiUSQYyK1VqMCeMkRTBL9pGJ1kukKfnakRe9qpdjwnUD-gpg95yQ-lrARxv806orruU3RyvPHn9H-PukUf4Pv1xtDdkZ1m3fh-Az9KMAfKffh53nw3G3cr-BeZOBHs
linkProvider Scholars Portal
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Seizure+Frequencies+and+Number+of+Anti-epileptic+Drugs+as+Risk+Factors+for+Sudden+Unexpected+Death+in+Epilepsy&rft.jtitle=Journal+of+Korean+medical+science&rft.au=Ryu%2C+Han+Uk&rft.au=Hong%2C+Jin+Pyo&rft.au=Han%2C+Su-Hyun&rft.au=Choi%2C+Eun+Ju&rft.date=2015-06-01&rft.issn=1598-6357&rft.eissn=1598-6357&rft.volume=30&rft.issue=6&rft.spage=788&rft_id=info:doi/10.3346%2Fjkms.2015.30.6.788&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1011-8934&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1011-8934&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1011-8934&client=summon