Glycoprotein 330/Megalin (LRP-2) Has Low Prevalence as mRNA and Protein in Brain Microvessels and Choroid Plexus
Prior studies indicated that glycoprotein 330 (gp330)/megalin mediates transcytosis of apolipoprotein J (apoJ) with Alzheimer's amyloide-peptide (Aβ) across the vascular membranes of the central nervous system (CNS). Here we show the presence of gp330/megalin mRNA and gp330-like immunoepitopes...
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Published in | Experimental neurology Vol. 157; no. 1; pp. 194 - 201 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Amsterdam
Elsevier Inc
01.05.1999
Elsevier |
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Abstract | Prior studies indicated that glycoprotein 330 (gp330)/megalin mediates transcytosis of apolipoprotein J (apoJ) with Alzheimer's amyloide-peptide (Aβ) across the vascular membranes of the central nervous system (CNS). Here we show the presence of gp330/megalin mRNA and gp330-like immunoepitopes in brain capillaries and choroid plexus and their absence from brain parenchyma. By polymerase chain reaction (PCR) we estimated 1.2 × 105molecules (1 pg) of gp330/megalin mRNA/μg total brain capillary RNA, which is 3% of that in kidney RNA. However, gp330 mRNA was not detected byin situhybridization in vascular CNS tissue, presumably because of low transcript prevalence. The ratio of gp330 protein:RNA was 17-fold higher in choroid plexus vs brain capillaries, which implies tissue specific regulation of the protein and mRNA prevalence. We conclude that gp330/megalin mRNA and protein are expressed in brain capillaries and choroid plexus in small amounts that are consistent with the observed activities of this endocytosing receptor in the regulation of apoJ and Aβ uptake by the CNS. |
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AbstractList | Prior studies indicated that glycoprotein 330 (gp330)/megalin mediates transcytosis of apolipoprotein J (apoJ) with Alzheimer's amyloide-peptide (Abeta) across the vascular membranes of the central nervous system (CNS). Here we show the presence of gp330/megalin mRNA and gp330-like immunoepitopes in brain capillaries and choroid plexus and their absence from brain parenchyma. By polymerase chain reaction (PCR) we estimated 1.2 x 10(5) molecules (1 pg) of gp330/megalin mRNA/microg total brain capillary RNA, which is 3% of that in kidney RNA. However, gp330 mRNA was not detected by in situ hybridization in vascular CNS tissue, presumably because of low transcript prevalence. The ratio of gp330 protein:RNA was 17-fold higher in choroid plexus vs brain capillaries, which implies tissue specific regulation of the protein and mRNA prevalence. We conclude that gp330/megalin mRNA and protein are expressed in brain capillaries and choroid plexus in small amounts that are consistent with the observed activities of this endocytosing receptor in the regulation of apoJ and Abeta uptake by the CNS. Prior studies indicated that glycoprotein 330 (gp330)/megalin mediates transcytosis of apolipoprotein J (apoJ) with Alzheimer's amyloide-peptide (Aβ) across the vascular membranes of the central nervous system (CNS). Here we show the presence of gp330/megalin mRNA and gp330-like immunoepitopes in brain capillaries and choroid plexus and their absence from brain parenchyma. By polymerase chain reaction (PCR) we estimated 1.2 × 105molecules (1 pg) of gp330/megalin mRNA/μg total brain capillary RNA, which is 3% of that in kidney RNA. However, gp330 mRNA was not detected byin situhybridization in vascular CNS tissue, presumably because of low transcript prevalence. The ratio of gp330 protein:RNA was 17-fold higher in choroid plexus vs brain capillaries, which implies tissue specific regulation of the protein and mRNA prevalence. We conclude that gp330/megalin mRNA and protein are expressed in brain capillaries and choroid plexus in small amounts that are consistent with the observed activities of this endocytosing receptor in the regulation of apoJ and Aβ uptake by the CNS. |
Author | Pasinetti, Giulio M. Wang, Liang Zlokovic, Berislav V. Chun, Jong T. Finch, Caleb E. |
Author_xml | – sequence: 1 givenname: Jong T. surname: Chun fullname: Chun, Jong T. organization: Andrus Gerontology Center and Department of Biological Sciences, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, California, 90033 – sequence: 2 givenname: Liang surname: Wang fullname: Wang, Liang organization: Department of Neurological Surgery and Division of Neurosurgery, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, California, 90033 – sequence: 3 givenname: Giulio M. surname: Pasinetti fullname: Pasinetti, Giulio M. organization: Neuroinflammatory Research Center, Department of Psychiatry, Mt. Sinai Medical Center, New York, New York, 10029 – sequence: 4 givenname: Caleb E. surname: Finch fullname: Finch, Caleb E. organization: Andrus Gerontology Center and Department of Biological Sciences, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, California, 90033 – sequence: 5 givenname: Berislav V. surname: Zlokovic fullname: Zlokovic, Berislav V. organization: Department of Neurological Surgery and Division of Neurosurgery, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, California, 90033 |
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Keywords | gp330 clusterin blood–brain barrier amyloid LDL receptor choroid plexus Choroid plexus Prevalence Rat Rodentia Central nervous system Blood brain barrier Uptake Clusterin Microcirculation Vertebrata Endocytosis Regulation(control) Mammalia β Amyloid protein Animal Blood vessel Blood capillary Brain (vertebrata) |
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Snippet | Prior studies indicated that glycoprotein 330 (gp330)/megalin mediates transcytosis of apolipoprotein J (apoJ) with Alzheimer's amyloide-peptide (Aβ) across... Prior studies indicated that glycoprotein 330 (gp330)/megalin mediates transcytosis of apolipoprotein J (apoJ) with Alzheimer's amyloide-peptide (Abeta) across... |
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SubjectTerms | amyloid Animals Biological and medical sciences Blood Vessels - metabolism blood–brain barrier Blotting, Northern Blotting, Western Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebrovascular Circulation - physiology choroid plexus Choroid Plexus - metabolism clusterin Fundamental and applied biological sciences. Psychology gp330 Heymann Nephritis Antigenic Complex Immunohistochemistry In Situ Hybridization LDL receptor Male Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Microcirculation - physiology Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Vertebrates: nervous system and sense organs |
Title | Glycoprotein 330/Megalin (LRP-2) Has Low Prevalence as mRNA and Protein in Brain Microvessels and Choroid Plexus |
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