Association of Five Snps in Cytotoxic T-Lymphocyte Antigen 4 and Cancer Susceptibility: Evidence from 67 Studies

• Published in: Cellular physiology and biochemistry Vol. 47; no. 1; pp. 414 - 427
• Main Authors: Fang, Min, Huang, Wencheng, Mo, Dan, Zhao, Wei, Huang, Rongyong
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2018; Cell Physiol Biochem Press GmbH & Co KG
• Subjects: Antigens; Asian Continental Ancestry Group - genetics; Breast cancer; Cancer susceptibility; Case-Control Studies; Cervical cancer; Ctla-4; CTLA-4 Antigen - genetics; Cytotoxicity; European Continental Ancestry Group - genetics; Genetic Predisposition to Disease; Genotype; Head & neck cancer; Humans; Lymphocytes; Meta-analysis; Neoplasms - epidemiology; Neoplasms - genetics; Original Paper; Pancreatic cancer; Polymerase chain reaction; Polymorphism, Single Nucleotide; Publication Bias; SNP; Cancer susceptibility; Ctla-4; SNP; Meta-analysis

Background/Aims: CTLA-4 polymorphisms are associated with susceptibility to various cancers, but the results are often conflicting. Hence, we performed a comprehensive meta-analysis to quantitatively investigate the association between CTLA-4 polymorphisms (rs231775, rs4553808，rs5742909, rs3087243 o...