Absence of accelerated atherosclerotic disease progression after intracoronary infusion of bone marrow derived mononuclear cells in patients with acute myocardial infarction—Angiographic and intravascular ultrasound—Results from the TErapia Celular Aplicada al Miocardio Pilot study

• Published in: The American heart journal Vol. 159; no. 6; pp. 1154.e1 - 1154.e8
• Main Authors: Arnold, Roman, MD, PhD, Villa, Adolfo, MD, Gutiérrez, Hipólito, MD, Sánchez, Pedro L., MD, PhD, Gimeno, Federico, MD, PhD, Fernández, Maria E., PhD, Gutiérrez, Oliver, MD, Mota, Pedro, MD, Sánchez, Ana, MD, PhD, García-Frade, Javier, MD, PhD, Fernández-Avilés, Francisco, MD, PhD, FACC, San Román, Jose A., MD, PhD, FESC
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 01.06.2010; Elsevier Limited
• Subjects: Angioplasty; Atherosclerosis - complications; Atherosclerosis - diagnosis; Atherosclerosis - surgery; Blood Component Transfusion - methods; Blood Transfusion, Autologous; Bone marrow; Cardiovascular; Coronary Angiography - methods; Coronary Artery Disease - complications; Coronary Artery Disease - diagnosis; Coronary Artery Disease - surgery; Coronary Vessels; Disease Progression; Female; Follow-Up Studies; Humans; Infusions, Intra-Arterial; Macrophages - transplantation; Male; Middle Aged; Myocardial Infarction - diagnosis; Myocardial Infarction - etiology; Myocardial Infarction - therapy; Pilot Projects; Retrospective Studies; Stem cells; Stents; Studies; Transplants & implants; Treatment Outcome; Ultrasonography, Interventional - methods; Veins & arteries

Background We tried to evaluate a putative negative effect on coronary atherosclerosis in patients receiving intracoronary infusion of unfractionated bone marrow mononuclear cells (BMMC) following an acute ST-elevation myocardial infarction. Peripheral blood mononuclear cells or enriched CD133+ BMMC...