The effects of prebiotics on microbial dysbiosis, butyrate production and immunity in HIV-infected subjects

• Published in: Mucosal immunology Vol. 10; no. 5; pp. 1279 - 1293
• Main Authors: Serrano-Villar, S., Vázquez-Castellanos, J.F., Vallejo, A., Latorre, A., Sainz, T., Ferrando-Martínez, S., Rojo, D., Martínez-Botas, J., del Romero, J., Madrid, N., Leal, M., Mosele, J.I., Motilva, M.J., Barbas, C., Ferrer, M., Moya, A., Moreno, S., Gosalbes, M.J., Estrada, V.
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 01.09.2017; Nature Publishing Group US; Elsevier Limited
• Subjects: 692/4020/1503/2745; 692/53; 692/699/255/1901; 692/700/459/1994; Adult; Allergology; Antibodies; Antiretroviral therapy; Bacteria - genetics; Biomedical and Life Sciences; Biomedicine; Butyrates - metabolism; C-reactive protein; CD14 antigen; Cell activation; Chronic infection; Dietary Supplements; Dysbacteriosis; Dysbiosis - etiology; Dysbiosis - microbiology; Dysbiosis - prevention & control; Fecal microflora; Feces - microbiology; Female; Gastroenterology; Gastrointestinal Microbiome - genetics; Gastrointestinal Microbiome - immunology; Genetic markers; Glutamine; HIV; HIV Infections - complications; HIV Infections - immunology; HIV Infections - microbiology; HIV-1 - immunology; Host-Pathogen Interactions; Human immunodeficiency virus; Humans; Immunity; Immunology; Immunopathogenesis; Inflammation; Intestinal microflora; Intestinal Mucosa - immunology; Intestinal Mucosa - microbiology; Intestinal Mucosa - virology; Lymphocytes T; Male; Microbiota; Middle Aged; Mucosa; Placebo Effect; Prebiotics; Prebiotics - administration & dosage; RNA, Ribosomal, 16S - analysis; rRNA 16S; Thymus

Altered interactions between the gut mucosa and bacteria during HIV infection seem to contribute to chronic immune dysfunction. A deeper understanding of how nutritional interventions could ameliorate gut dysbiosis is needed. Forty-four subjects, including 12 HIV+ viremic untreated (VU) patients, 23...