Exploring the Impact of Morphology on the Properties of Biodegradable Nanoparticles and Their Diffusion in Complex Biological Medium

• Published in: Biomacromolecules Vol. 22; no. 1; pp. 126 - 133
• Main Authors: Ridolfo, Roxane, Tavakoli, Shirin, Junnuthula, Vijayabhaskarreddy, Williams, David S., Urtti, Arto, van Hest, Jan C. M.
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 11.01.2021
• Subjects: biodegradability; composite polymers; dexamethasone; micelles; retina; solubility; surfactants; therapeutics

Nanoparticle morphology (size, shape, and composition) and surface chemistry are the determining factors underpinning the efficacy of such materials in therapeutic applications. The size, shape, and surface chemistry of a nanoparticle can strongly influence key properties such as interactions with d...