Genetic polymorphisms in APE1 Asp148Glu(rs3136820) as a modifier of the background levels of abasic sites in human leukocytes derived from breast cancer patients and controls

• Published in: Breast cancer (Tokyo, Japan) Vol. 24; no. 3; pp. 420 - 426
• Main Authors: Hsieh, Wei-Chung, Lin, Che, Chen, Dar-Ren, Yu, Wen-Fa, Chen, Guan-Jie, Hu, Suh-Woan, Liu, Chin-Chen, Ge, Mao-Huei, Ruan, Chang-Sin, Chen, Cheng-You, Lin, Chia-Hua, Lin, Po-Hsiung
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.05.2017; Springer
• Subjects: Adult; Body mass index; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Cancer; Cancer Research; Care and treatment; Case-Control Studies; Development and progression; DNA - metabolism; DNA Damage; DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics; Female; Gene Frequency; Genetic aspects; Genetic polymorphisms; Genetic Predisposition to Disease; Health aspects; Humans; Leukocytes - pathology; Medicine; Medicine & Public Health; Middle Aged; Nucleases; Oncology; Oncology, Experimental; Original Article; Polymorphism, Single Nucleotide; Putrescine - metabolism; Risk factors; Surgery; Surgical Oncology; Oxidative stress; Biomarker; AP sites; DNA repair

Background Apurinic/apyrimidinic (abasic/AP) sites are among the most common endogenous DNA lesions. AP sites, if not repaired, could result in genomic instability as well as chromosome aberrations. Information regarding the direct assay of the number of abasic sites in human leukocytes and its asso...