Effects of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on All-Cause Mortality and Renal Outcomes in Patients with Diabetes and Albuminuria: a Systematic Review and Meta-Analysis

• Published in: Kidney & blood pressure research Vol. 43; no. 3; pp. 768 - 779
• Main Authors: Wang, Kanran, Hu, Jinbo, Luo, Ting, Wang, Yue, Yang, Shumin, Qing, Hua, Cheng, Qingfeng, Li, Qifu
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2018; Karger Publishers
• Subjects: Albuminuria - complications; Albuminuria - drug therapy; Albuminuria - mortality; Albuminuria regression; All-cause mortality; Angiotensin II; Angiotensin II receptor blockers; Angiotensin Receptor Antagonists - pharmacology; Angiotensin Receptor Antagonists - therapeutic use; Angiotensin-converting enzyme inhibitors; Angiotensin-Converting Enzyme Inhibitors - pharmacology; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Angiotensin-converting enzyme(ACE) inhibitors; Blood pressure; Cardiovascular Diseases - drug therapy; Clinical trials; Creatinine; Creatinine - blood; Data processing; Diabetes; Diabetes mellitus; Diabetes Mellitus - drug therapy; Doubling of serum creatinine; Drug dosages; End-stage renal disease; Enzyme inhibitors; Enzymes; Health risks; Humans; Hypertension; Kidney diseases; Kidney Failure, Chronic - drug therapy; Macroalbuminuria; Medical Subject Headings-MeSH; Meta-analysis; Microalbuminuria; Mortality; Original Paper; Patients; Peptidyl-dipeptidase A; Randomized Controlled Trials as Topic; Reno-protective effect; Risk; Studies; Subgroups; Systematic review; Treatment Outcome; Urine; End-stage renal disease; Albuminuria regression; All-cause mortality; Reno-protective effect; Angiotensin II receptor blockers; Diabetes; Angiotensin-converting enzyme(ACE) inhibitors; Doubling of serum creatinine; Macroalbuminuria; Microalbuminuria; Meta-analysis

Background/Aims: Whether angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARB) could benefit patients with diabetes and albuminuria remains controversial. A systematic review and meta-analysis were conducted to answer this question by comparing ACE inhibitors or AR...