Ursodeoxycholic acid therapy and liver transplant-free survival in patients with primary biliary cholangitis

• Published in: Journal of hepatology Vol. 71; no. 2; pp. 357 - 365
• Main Authors: Harms, Maren H., van Buuren, Henk R., Corpechot, Christophe, Thorburn, Douglas, Janssen, Harry L.A., Lindor, Keith D., Hirschfield, Gideon M., Parés, Albert, Floreani, Annarosa, Mayo, Marlyn J., Invernizzi, Pietro, Battezzati, Pier Maria, Nevens, Frederik, Ponsioen, Cyriel Y., Mason, Andrew L., Kowdley, Kris V., Lammers, Willem J., Hansen, Bettina E., van der Meer, Adriaan J.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2019; Elsevier Science Ltd
• Subjects: Acids; Adult; Aged; Bile; Cholagogues and Choleretics - therapeutic use; Cholangitis; Cholangitis - complications; Cholangitis - drug therapy; Cholangitis - mortality; Cholangitis - surgery; Cholestasis; Clinical trials; Death; Disease Progression; Female; Follow-Up Studies; Humans; Liver; Liver Cirrhosis, Biliary - complications; Liver Transplantation; Male; Middle Aged; Mortality; Patient management; Patients; Proportional Hazards Models; Risk; Statistical analysis; Survival; Survival Rate; Treatment; Treatment Outcome; UDCA, transplantation; Ursodeoxycholic acid; Ursodeoxycholic Acid - therapeutic use; Clinical trials; Treatment; Patient management; UDCA, transplantation; Mortality; Cholestasis

[Display omitted] •Ursodeoxycholic acid is associated with prolonged survival in primary biliary cholangitis.•This positive association is significant irrespective of age, sex, or disease stage.•The association remains significant in cases where the established criteria for therapeutic response are...