Hyaluronic acid from bluefin tuna by-product: Structural analysis and pharmacological activities
The fishing and aquaculture industries generate a huge amount of waste during processing and preservation operations, especially those of tuna. Recovering these by-products is a major economic and environmental challenge for manufacturers seeking to produce new active biomolecules of interest. A new...
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| Published in | International journal of biological macromolecules Vol. 264; no. Pt 1; p. 130424 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.04.2024
Elsevier |
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| Online Access | Get full text |
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| Abstract | The fishing and aquaculture industries generate a huge amount of waste during processing and preservation operations, especially those of tuna. Recovering these by-products is a major economic and environmental challenge for manufacturers seeking to produce new active biomolecules of interest. A new hyaluronic acid was extracted from bluefin tuna's vitreous humour to assess its antioxidant and pharmacological activities. The characterization by infrared spectroscopy (FT-IR), nuclear magnetic resonance ((1D1H) and 2D (1H COSY, 1H/13C HSQC)) and size exclusion chromatography (SEC/MALS/DRI/VD) revealed that the extracted polysaccharide was a hyaluronic acid with high uronic acid content (55.8 %) and a weight average molecular weight of 888 kDa. This polymer possesses significant anti-radical activity and ferrous chelating capacity. In addition, pharmacological evaluation of its anti-inflammatory and analgesic potential, using preclinical models, in comparison with reference drugs (Dexamethasone, diclofenac, and acetylsalicylate of lysine), revealed promising anti-inflammatory activity as well as interesting peripheral and central antinociceptive activity. Therefore, our new hyaluronic acid compound may therefore serve as a potential drug candidate for the treatment of pain sensation and inflammation of various pathological origins.
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•A novel hyaluronic acid was extracted from the vitreous humour of bluefin tuna.•The physicochemical properties of the isolated hyaluronic acid were studied.•The isolated hyaluronic acid demonstrated significant pharmacological properties.•The hyaluronic acid demonstrated promising potential as an anti-inflammatory agent. |
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| AbstractList | The fishing and aquaculture industries generate a huge amount of waste during processing and preservation operations, especially those of tuna. Recovering these by-products is a major economic and environmental challenge for manufacturers seeking to produce new active biomolecules of interest. A new hyaluronic acid was extracted from bluefin tuna's vitreous humour to assess its antioxidant and pharmacological activities. The characterization by infrared spectroscopy (FT-IR), nuclear magnetic resonance ((¹D¹H) and 2D (¹H COSY, ¹H/¹³C HSQC)) and size exclusion chromatography (SEC/MALS/DRI/VD) revealed that the extracted polysaccharide was a hyaluronic acid with high uronic acid content (55.8 %) and a weight average molecular weight of 888 kDa. This polymer possesses significant anti-radical activity and ferrous chelating capacity. In addition, pharmacological evaluation of its anti-inflammatory and analgesic potential, using preclinical models, in comparison with reference drugs (Dexamethasone, diclofenac, and acetylsalicylate of lysine), revealed promising anti-inflammatory activity as well as interesting peripheral and central antinociceptive activity. Therefore, our new hyaluronic acid compound may therefore serve as a potential drug candidate for the treatment of pain sensation and inflammation of various pathological origins. The fishing and aquaculture industries generate a huge amount of waste during processing and preservation operations, especially those of tuna. Recovering these by-products is a major economic and environmental challenge for manufacturers seeking to produce new active biomolecules of interest. A new hyaluronic acid was extracted from bluefin tuna's vitreous humour to assess its antioxidant and pharmacological activities. The characterization by infrared spectroscopy (FT-IR), nuclear magnetic resonance ((1D1H) and 2D (1H COSY, 1H/13C HSQC)) and size exclusion chromatography (SEC/MALS/DRI/VD) revealed that the extracted polysaccharide was a hyaluronic acid with high uronic acid content (55.8 %) and a weight average molecular weight of 888 kDa. This polymer possesses significant anti-radical activity and ferrous chelating capacity. In addition, pharmacological evaluation of its anti-inflammatory and analgesic potential, using preclinical models, in comparison with reference drugs (Dexamethasone, diclofenac, and acetylsalicylate of lysine), revealed promising anti-inflammatory activity as well as interesting peripheral and central antinociceptive activity. Therefore, our new hyaluronic acid compound may therefore serve as a potential drug candidate for the treatment of pain sensation and inflammation of various pathological origins. [Display omitted] •A novel hyaluronic acid was extracted from the vitreous humour of bluefin tuna.•The physicochemical properties of the isolated hyaluronic acid were studied.•The isolated hyaluronic acid demonstrated significant pharmacological properties.•The hyaluronic acid demonstrated promising potential as an anti-inflammatory agent. The fishing and aquaculture industries generate a huge amount of waste during processing and preservation operations, especially those of tuna. Recovering these by-products is a major economic and environmental challenge for manufacturers seeking to produce new active biomolecules of interest. A new hyaluronic acid was extracted from bluefin tuna's vitreous humour to assess its antioxidant and pharmacological activities. The characterization by infrared spectroscopy (FT-IR), nuclear magnetic resonance (( D H) and 2D ( H COSY, H/ C HSQC)) and size exclusion chromatography (SEC/MALS/DRI/VD) revealed that the extracted polysaccharide was a hyaluronic acid with high uronic acid content (55.8 %) and a weight average molecular weight of 888 kDa. This polymer possesses significant anti-radical activity and ferrous chelating capacity. In addition, pharmacological evaluation of its anti-inflammatory and analgesic potential, using preclinical models, in comparison with reference drugs (Dexamethasone, diclofenac, and acetylsalicylate of lysine), revealed promising anti-inflammatory activity as well as interesting peripheral and central antinociceptive activity. Therefore, our new hyaluronic acid compound may therefore serve as a potential drug candidate for the treatment of pain sensation and inflammation of various pathological origins. The fishing and aquaculture industries generate a huge amount of waste during processing and preservation operations, especially those of tuna. Recovering these by-products is a major economic and environmental challenge for manufacturers seeking to produce new active biomolecules of interest. A new hyaluronic acid was extracted from bluefin tuna's vitreous humour to assess its antioxidant and pharmacological activities. The characterization by infrared spectroscopy (FT-IR), nuclear magnetic resonance ((1D1H) and 2D (1H COSY, 1H/13C HSQC)) and size exclusion chromatography (SEC/MALS/DRI/VD) revealed that the extracted polysaccharide was a hyaluronic acid with high uronic acid content (55.8 %) and a weight average molecular weight of 888 kDa. This polymer possesses significant anti-radical activity and ferrous chelating capacity. In addition, pharmacological evaluation of its anti-inflammatory and analgesic potential, using preclinical models, in comparison with reference drugs (Dexamethasone, diclofenac, and acetylsalicylate of lysine), revealed promising anti-inflammatory activity as well as interesting peripheral and central antinociceptive activity. Therefore, our new hyaluronic acid compound may therefore serve as a potential drug candidate for the treatment of pain sensation and inflammation of various pathological origins.The fishing and aquaculture industries generate a huge amount of waste during processing and preservation operations, especially those of tuna. Recovering these by-products is a major economic and environmental challenge for manufacturers seeking to produce new active biomolecules of interest. A new hyaluronic acid was extracted from bluefin tuna's vitreous humour to assess its antioxidant and pharmacological activities. The characterization by infrared spectroscopy (FT-IR), nuclear magnetic resonance ((1D1H) and 2D (1H COSY, 1H/13C HSQC)) and size exclusion chromatography (SEC/MALS/DRI/VD) revealed that the extracted polysaccharide was a hyaluronic acid with high uronic acid content (55.8 %) and a weight average molecular weight of 888 kDa. This polymer possesses significant anti-radical activity and ferrous chelating capacity. In addition, pharmacological evaluation of its anti-inflammatory and analgesic potential, using preclinical models, in comparison with reference drugs (Dexamethasone, diclofenac, and acetylsalicylate of lysine), revealed promising anti-inflammatory activity as well as interesting peripheral and central antinociceptive activity. Therefore, our new hyaluronic acid compound may therefore serve as a potential drug candidate for the treatment of pain sensation and inflammation of various pathological origins. |
| ArticleNumber | 130424 |
| Author | Elhiss, Sawsen Bouchemal, Nadia Majdoub, Hatem Laschet, Jamila Boisson-Vidal, Catherine Chaubet, Frédéric Chahed, Latifa Le Cerf, Didier Maaroufi, Raoui Mounir Hamdi, Assia Kraiem, Jamil Ben Mansour, Mohamed |
| Author_xml | – sequence: 1 givenname: Sawsen surname: Elhiss fullname: Elhiss, Sawsen organization: Laboratoire de Génétique, Biodiversité et Valorisation des Bioressources (LR11ES41), University of Monastir, Tunisia – sequence: 2 givenname: Assia surname: Hamdi fullname: Hamdi, Assia organization: Laboratory of Chemical, Galenic and Pharmacological Development of Drugs, Faculty of Pharmacy, Monastir 5000, Tunisia – sequence: 3 givenname: Latifa surname: Chahed fullname: Chahed, Latifa organization: Laboratoire de Génétique, Biodiversité et Valorisation des Bioressources (LR11ES41), University of Monastir, Tunisia – sequence: 4 givenname: Catherine surname: Boisson-Vidal fullname: Boisson-Vidal, Catherine organization: Université Paris Cité, INSERM, Innovative Therapies in Haemostasis, F-75006 Paris, France – sequence: 5 givenname: Hatem surname: Majdoub fullname: Majdoub, Hatem organization: Laboratory of Interfaces and Advanced Materials, Faculty of Sciences of Monastir, University of Monastir, Monastir, Tunisia – sequence: 6 givenname: Nadia surname: Bouchemal fullname: Bouchemal, Nadia organization: Université Sorbonne Paris Nord, CNRS, CSPBAT, F-93000 Bobigny, France – sequence: 7 givenname: Jamila surname: Laschet fullname: Laschet, Jamila organization: Université Sorbonne Paris Nord, INSERM, LVTS, F-75018 Paris, France – sequence: 8 givenname: Jamil surname: Kraiem fullname: Kraiem, Jamil organization: Laboratory of Chemical, Galenic and Pharmacological Development of Drugs, Faculty of Pharmacy, Monastir 5000, Tunisia – sequence: 9 givenname: Didier surname: Le Cerf fullname: Le Cerf, Didier organization: Université Rouen Normandie, INSA Rouen Normandie, CNRS, Normandie Univ, PBS UMR 6270, 76000 Rouen, France – sequence: 10 givenname: Raoui Mounir surname: Maaroufi fullname: Maaroufi, Raoui Mounir organization: Laboratoire de Génétique, Biodiversité et Valorisation des Bioressources (LR11ES41), University of Monastir, Tunisia – sequence: 11 givenname: Frédéric surname: Chaubet fullname: Chaubet, Frédéric organization: Université Sorbonne Paris Nord, INSERM, LVTS, F-75018 Paris, France – sequence: 12 givenname: Mohamed surname: Ben Mansour fullname: Ben Mansour, Mohamed email: benmansourissat@gmail.com organization: Laboratoire de Génétique, Biodiversité et Valorisation des Bioressources (LR11ES41), University of Monastir, Tunisia |
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| Keywords | SEC/MALS/DRI/VD Vitreous humour Marine waste Hyaluronic acid Pharmacological activities Antioxidant property |
| Language | English |
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| Title | Hyaluronic acid from bluefin tuna by-product: Structural analysis and pharmacological activities |
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