LIF is a contraction-induced myokine stimulating human myocyte proliferation

• Published in: Journal of applied physiology (1985) Vol. 111; no. 1; pp. 251 - 259
• Main Authors: Broholm, Christa, Laye, Matthew J., Brandt, Claus, Vadalasetty, Radhika, Pilegaard, Henriette, Pedersen, Bente Klarlund, Scheele, Camilla
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Physiological Society 01.07.2011
• Subjects: Adult; Biological and medical sciences; Biopsy; Cell Communication - drug effects; Cell Proliferation - drug effects; Cells, Cultured; Cytokines; Electric Stimulation; Exercise; Fundamental and applied biological sciences. Psychology; Humans; Leukemia; Leukemia Inhibitory Factor - genetics; Leukemia Inhibitory Factor - metabolism; Male; Molecules; Muscle Contraction; Muscle Fibers, Skeletal - drug effects; Muscle Fibers, Skeletal - metabolism; Musculoskeletal system; Phosphatidylinositol 3-Kinases - antagonists & inhibitors; Phosphatidylinositol 3-Kinases - metabolism; Phosphorylation; Protein Kinase Inhibitors - pharmacology; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; Proto-Oncogene Proteins c-jun - metabolism; Proto-Oncogene Proteins c-myc - metabolism; Quadriceps Muscle - drug effects; Quadriceps Muscle - metabolism; Receptors, OSM-LIF - genetics; Receptors, OSM-LIF - metabolism; Recombinant Proteins - metabolism; Resistance Training; Ribonucleic acid; RNA; RNA Interference; RNA, Messenger - metabolism; Satellite Cells, Skeletal Muscle - metabolism; Time Factors; TOR Serine-Threonine Kinases - antagonists & inhibitors; TOR Serine-Threonine Kinases - metabolism; Young Adult; Physical exercise; Human; Cell proliferation; Leukemia inhibitory factor; Striated muscle; Muscle contraction; Myocyte; Vertebrata; Mammalia; resistance exercise; Satellite cell; skeletal muscle; satellite cells
• ISSN: 8750-7587; 1522-1601; 1522-1601
• DOI: 10.1152/japplphysiol.01399.2010

The cytokine leukemia inhibitory factor (LIF) is expressed by skeletal muscle and induces proliferation of myoblasts. We hypothesized that LIF is a contraction-induced myokine functioning in an autocrine fashion to activate gene regulation of human muscle satellite cell proliferation. Skeletal muscl...