Laundry detergents and detergent residue after rinsing directly disrupt tight junction barrier integrity in human bronchial epithelial cells

• Published in: Journal of allergy and clinical immunology Vol. 143; no. 5; pp. 1892 - 1903
• Main Authors: Wang, Ming, Tan, Ge, Eljaszewicz, Andrzej, Meng, Yifan, Wawrzyniak, Paulina, Acharya, Swati, Altunbulakli, Can, Westermann, Patrick, Dreher, Anita, Yan, Liying, Wang, Chengshuo, Akdis, Mubeccel, Zhang, Luo, Nadeau, Kari C., Akdis, Cezmi A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2019; Elsevier Limited
• Subjects: Alarmins - genetics; Alarmins - metabolism; Allergies; Alveolar Epithelial Cells - metabolism; Alveolar Epithelial Cells - pathology; Apoptosis; Asthma; Asthma - metabolism; barrier function; Bronchi - pathology; bronchial epithelial cells; Cell adhesion; Cell adhesion & migration; Cell culture; Cell size; Cells, Cultured; Chromatin; Chronic obstructive pulmonary disease; Cytotoxicity; Deoxyribonucleic acid; Detergent industry; Detergents; Detergents - metabolism; DNA; DNA methylation; DNA sequencing; Electric Impedance; epigenome; Epithelial cells; Gene expression; Gene Expression Regulation; Health care; High-Throughput Nucleotide Sequencing; Households; Humans; L-Lactate dehydrogenase; L-Lactate Dehydrogenase - metabolism; Lactic acid; Laundry; Laundry detergent; Lipid Metabolism; Lung diseases; Metabolism; Next-generation sequencing; Obstructive lung disease; Public health; Ribonucleic acid; rinse residue; RNA; Studies; Surfactants; tight junction; Tight Junctions - metabolism; Tight Junctions - pathology; transcriptome; Transposase; Switzerland; TER; bronchial epithelial cells; SDBS; transcriptome; Laundry detergent; ATAC-seq; BP; LDH; FITC; RNA-seq; rinse residue; barrier function; tight junction; epigenome; TSLP; DMP; DEG; GO; asthma; ZO-1; UPLC; TJ; HBEC; ALI; chronic obstructive pulmonary disease; COPD

Defects in the epithelial barrier have recently been associated with asthma and other allergies. The influence of laundry detergents on human bronchial epithelial cells (HBECs) and their barrier function remain unknown. We investigated the effects of laundry detergents on cytotoxicity, barrier funct...