Serotonin 2A receptor agonist binding in the human brain with [11C]Cimbi-36: Test–retest reproducibility and head-to-head comparison with the antagonist [18F]altanserin

• Published in: NeuroImage (Orlando, Fla.) Vol. 130; pp. 167 - 174
• Main Authors: Ettrup, Anders, Svarer, Claus, McMahon, Brenda, da Cunha-Bang, Sofi, Lehel, Szabolcs, Møller, Kirsten, Dyssegaard, Agnete, Ganz, Melanie, Beliveau, Vincent, Jørgensen, Louise Møller, Gillings, Nic, Knudsen, Gitte Moos
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.04.2016; Elsevier Limited
• Subjects: 5-HT; Agonist; Agonists; Benzylamines - metabolism; Benzylamines - pharmacokinetics; Brain; Brain - metabolism; Carbon Radioisotopes - metabolism; Carbon Radioisotopes - pharmacokinetics; Choroid plexus; Cortex; Female; Fluorine Radioisotopes - metabolism; Fluorine Radioisotopes - pharmacokinetics; Hippocampus; Humans; Ketanserin - analogs & derivatives; Ketanserin - metabolism; Ketanserin - pharmacokinetics; LSD; Lysergic acid diethylamide; Male; Medical imaging; Neuroimaging; Neuroimaging - methods; Phenethylamines - metabolism; Phenethylamines - pharmacokinetics; Positron emission tomography; Positron-Emission Tomography - methods; Radioisotopes; Radiopharmaceuticals - metabolism; Radiopharmaceuticals - pharmacokinetics; Radiotracer evaluation; Receptor density; Reproducibility; Reproducibility of Results; Serotonin 5-HT2 Receptor Agonists - metabolism; Serotonin 5-HT2 Receptor Agonists - pharmacokinetics; Serotonin 5-HT2 Receptor Antagonists - metabolism; Serotonin 5-HT2 Receptor Antagonists - pharmacokinetics; Serotonin S2 receptors; Test–retest variability; Tomography; Young Adult; Neuroimaging; Agonist; 5-HT; Positron emission tomography; Radiotracer evaluation; Test–retest variability

[11C]Cimbi-36 is a recently developed serotonin 2A (5-HT2A) receptor agonist positron emission tomography (PET) radioligand that has been successfully applied for human neuroimaging. Here, we investigate the test–retest variability of cerebral [11C]Cimbi-36 PET and compare [11C]Cimbi-36 and the 5-HT...