A phosphorescent silver(I)–gold (I) cluster complex that specifically lights up the nucleolus of living cells with FLIM imaging

Abstract The phosphorescent silver(I)–gold(I) cluster complex [CAu6 Ag 2dppy 6 ](BF4 )4 ( N1 ) selectively stains the nucleolus, with a much lower uptake in the nucleus and cytoplasm, and exhibits excellent photostability. This Ag–Au cluster, which has a photoluminescent lifetime of microseconds, is...

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Published inBiomaterials Vol. 34; no. 17; pp. 4284 - 4295
Main Authors Chen, Min, Lei, Zhen, Feng, Wei, Li, Chunyan, Wang, Quan-Ming, Li, Fuyou
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.06.2013
Subjects
Advanced Basic Science
Biological Transport
Cell Cycle
Cell Death
Cell Line, Tumor
Cell Nucleolus - metabolism
Cell Survival
Dentistry
Endocytosis
FLIM imaging
Flow Cytometry
Gold - chemistry
Humans
Imaging, Three-Dimensional
Kinetics
Luminescent Measurements
Microscopy, Confocal
Microscopy, Fluorescence - methods
Nucleolus
Photobleaching
Selective staining
Silver - chemistry
Silver(I)–gold (I) cluster complex
Spectrophotometry, Atomic
Staining and Labeling
Temperature
Silver(I)–gold (I) cluster complex
Selective staining
FLIM imaging
Nucleolus
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Abstract Abstract The phosphorescent silver(I)–gold(I) cluster complex [CAu6 Ag 2dppy 6 ](BF4 )4 ( N1 ) selectively stains the nucleolus, with a much lower uptake in the nucleus and cytoplasm, and exhibits excellent photostability. This Ag–Au cluster, which has a photoluminescent lifetime of microseconds, is particularly attractive as a probe in applications of time-gated microscopy. Investigation of the pathway of cellular entry indicated that N1 permeates the outer membrane and nuclear membrane of living cells through an energy-dependent and non-endocytic route within 10 min. High concentrations of N1 in the nucleolus have been quantified by inductively coupled plasma atomic emission spectroscopy (ICP-AES) and transmission electron microscopy coupled with an energy dispersive X-ray analysis (TEM-EDXA), which also helped to elucidate the mechanism of the specific staining. Intracellular selective staining may be correlated with the microenvironment of the nucleolus, which is consistent with experiments conducted at different phases of the cell cycle. These results prove that N1 is a very attractive phosphorescent staining reagent for visualizing the nucleolus of living cells.
AbstractList The phosphorescent silver(I)-gold(I) cluster complex [CAu6Ag2(dppy)6](BF4)4 (N1) selectively stains the nucleolus, with a much lower uptake in the nucleus and cytoplasm, and exhibits excellent photostability. This Ag-Au cluster, which has a photoluminescent lifetime of microseconds, is particularly attractive as a probe in applications of time-gated microscopy. Investigation of the pathway of cellular entry indicated that N1 permeates the outer membrane and nuclear membrane of living cells through an energy-dependent and non-endocytic route within 10 min. High concentrations of N1 in the nucleolus have been quantified by inductively coupled plasma atomic emission spectroscopy (ICP-AES) and transmission electron microscopy coupled with an energy dispersive X-ray analysis (TEM-EDXA), which also helped to elucidate the mechanism of the specific staining. Intracellular selective staining may be correlated with the microenvironment of the nucleolus, which is consistent with experiments conducted at different phases of the cell cycle. These results prove that N1 is a very attractive phosphorescent staining reagent for visualizing the nucleolus of living cells.
Abstract The phosphorescent silver(I)–gold(I) cluster complex [CAu6 Ag 2dppy 6 ](BF4 )4 ( N1 ) selectively stains the nucleolus, with a much lower uptake in the nucleus and cytoplasm, and exhibits excellent photostability. This Ag–Au cluster, which has a photoluminescent lifetime of microseconds, is particularly attractive as a probe in applications of time-gated microscopy. Investigation of the pathway of cellular entry indicated that N1 permeates the outer membrane and nuclear membrane of living cells through an energy-dependent and non-endocytic route within 10 min. High concentrations of N1 in the nucleolus have been quantified by inductively coupled plasma atomic emission spectroscopy (ICP-AES) and transmission electron microscopy coupled with an energy dispersive X-ray analysis (TEM-EDXA), which also helped to elucidate the mechanism of the specific staining. Intracellular selective staining may be correlated with the microenvironment of the nucleolus, which is consistent with experiments conducted at different phases of the cell cycle. These results prove that N1 is a very attractive phosphorescent staining reagent for visualizing the nucleolus of living cells.
The phosphorescent silver(I)–gold(I) cluster complex [CAu6Ag2(dppy)6](BF4)4 (N1) selectively stains the nucleolus, with a much lower uptake in the nucleus and cytoplasm, and exhibits excellent photostability. This Ag–Au cluster, which has a photoluminescent lifetime of microseconds, is particularly attractive as a probe in applications of time-gated microscopy. Investigation of the pathway of cellular entry indicated that N1 permeates the outer membrane and nuclear membrane of living cells through an energy-dependent and non-endocytic route within 10 min. High concentrations of N1 in the nucleolus have been quantified by inductively coupled plasma atomic emission spectroscopy (ICP-AES) and transmission electron microscopy coupled with an energy dispersive X-ray analysis (TEM-EDXA), which also helped to elucidate the mechanism of the specific staining. Intracellular selective staining may be correlated with the microenvironment of the nucleolus, which is consistent with experiments conducted at different phases of the cell cycle. These results prove that N1 is a very attractive phosphorescent staining reagent for visualizing the nucleolus of living cells.
Author Chen, Min
Lei, Zhen
Wang, Quan-Ming
Li, Fuyou
Li, Chunyan
Feng, Wei
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Keywords Silver(I)–gold (I) cluster complex
Selective staining
FLIM imaging
Nucleolus
Language English
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SSID ssj0014042
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Snippet Abstract The phosphorescent silver(I)–gold(I) cluster complex [CAu6 Ag 2dppy 6 ](BF4 )4 ( N1 ) selectively stains the nucleolus, with a much lower uptake in...
The phosphorescent silver(I)–gold(I) cluster complex [CAu6Ag2(dppy)6](BF4)4 (N1) selectively stains the nucleolus, with a much lower uptake in the nucleus and...
The phosphorescent silver(I)-gold(I) cluster complex [CAu6Ag2(dppy)6](BF4)4 (N1) selectively stains the nucleolus, with a much lower uptake in the nucleus and...
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SubjectTerms Advanced Basic Science
Biological Transport
Cell Cycle
Cell Death
Cell Line, Tumor
Cell Nucleolus - metabolism
Cell Survival
Dentistry
Endocytosis
FLIM imaging
Flow Cytometry
Gold - chemistry
Humans
Imaging, Three-Dimensional
Kinetics
Luminescent Measurements
Microscopy, Confocal
Microscopy, Fluorescence - methods
Nucleolus
Photobleaching
Selective staining
Silver - chemistry
Silver(I)–gold (I) cluster complex
Spectrophotometry, Atomic
Staining and Labeling
Temperature
Title A phosphorescent silver(I)–gold (I) cluster complex that specifically lights up the nucleolus of living cells with FLIM imaging
URI https://www.clinicalkey.es/playcontent/1-s2.0-S0142961213002019
https://dx.doi.org/10.1016/j.biomaterials.2013.02.032
https://www.ncbi.nlm.nih.gov/pubmed/23489922
https://search.proquest.com/docview/1319618131
Volume 34
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