Prevention of Comorbidity and Acute Attack of Gout by Uric Acid Lowering Therapy
The object of this study was to evaluate the effect of uric acid lowering therapy in reducing the new development of comorbidities and the frequency of acute attacks in gout patients. We retrospectively reviewed patients who were diagnosed to have gout with at least 3 yr of follow up. They were divi...
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| Published in | Journal of Korean medical science Vol. 29; no. 5; pp. 657 - 661 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
The Korean Academy of Medical Sciences
01.05.2014
대한의학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1011-8934 1598-6357 1598-6357 |
| DOI | 10.3346/jkms.2014.29.5.657 |
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| Abstract | The object of this study was to evaluate the effect of uric acid lowering therapy in reducing the new development of comorbidities and the frequency of acute attacks in gout patients. We retrospectively reviewed patients who were diagnosed to have gout with at least 3 yr of follow up. They were divided into 2 groups; 53 patients with mean serum uric acid level (sUA)<6 mg/dL and 147 patients with mean sUA≥6 mg/dL. Comorbidities of gout such as hypertension (HTN), type II diabetes mellitus (DM), chronic kidney disease, cardiovascular disease (CVD) and urolithiasis were compared in each group at baseline and at last follow-up visit. Frequency of acute gout attacks were also compared between the groups. During the mean follow up period of 7.6 yr, the yearly rate of acute attack and the new development of HTN, DM, CVD and urolithiasis was lower in the adequately treated group compared to the inadequately treated group. Tight control of uric acid decreases the incidence of acute gout attacks and comorbidities of gout such as HTN, DM, CVD and urolithiasis. |
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| AbstractList | The object of this study was to evaluate the effect of uric acid lowering therapy in reducingthe new development of comorbidities and the frequency of acute attacks in goutpatients. We retrospectively reviewed patients who were diagnosed to have gout with atleast 3 yr of follow up. They were divided into 2 groups; 53 patients with mean serum uricacid level (sUA) < 6 mg/dL and 147 patients with mean sUA ≥ 6 mg/dL. Comorbidities ofgout such as hypertension (HTN), type II diabetes mellitus (DM), chronic kidney disease,cardiovascular disease (CVD) and urolithiasis were compared in each group at baseline andat last follow-up visit. Frequency of acute gout attacks were also compared between thegroups. During the mean follow up period of 7.6 yr, the yearly rate of acute attack andthe new development of HTN, DM, CVD and urolithiasis was lower in the adequatelytreated group compared to the inadequately treated group. Tight control of uric aciddecreases the incidence of acute gout attacks and comorbidities of gout such as HTN, DM,CVD and urolithiasis. KCI Citation Count: 1 The object of this study was to evaluate the effect of uric acid lowering therapy in reducing the new development of comorbidities and the frequency of acute attacks in gout patients. We retrospectively reviewed patients who were diagnosed to have gout with at least 3 yr of follow up. They were divided into 2 groups; 53 patients with mean serum uric acid level (sUA)<6 mg/dL and 147 patients with mean sUA≥6 mg/dL. Comorbidities of gout such as hypertension (HTN), type II diabetes mellitus (DM), chronic kidney disease, cardiovascular disease (CVD) and urolithiasis were compared in each group at baseline and at last follow-up visit. Frequency of acute gout attacks were also compared between the groups. During the mean follow up period of 7.6 yr, the yearly rate of acute attack and the new development of HTN, DM, CVD and urolithiasis was lower in the adequately treated group compared to the inadequately treated group. Tight control of uric acid decreases the incidence of acute gout attacks and comorbidities of gout such as HTN, DM, CVD and urolithiasis. The object of this study was to evaluate the effect of uric acid lowering therapy in reducing the new development of comorbidities and the frequency of acute attacks in gout patients. We retrospectively reviewed patients who were diagnosed to have gout with at least 3 yr of follow up. They were divided into 2 groups; 53 patients with mean serum uric acid level (sUA)<6 mg/dL and 147 patients with mean sUA≥6 mg/dL. Comorbidities of gout such as hypertension (HTN), type II diabetes mellitus (DM), chronic kidney disease, cardiovascular disease (CVD) and urolithiasis were compared in each group at baseline and at last follow-up visit. Frequency of acute gout attacks were also compared between the groups. During the mean follow up period of 7.6 yr, the yearly rate of acute attack and the new development of HTN, DM, CVD and urolithiasis was lower in the adequately treated group compared to the inadequately treated group. Tight control of uric acid decreases the incidence of acute gout attacks and comorbidities of gout such as HTN, DM, CVD and urolithiasis.The object of this study was to evaluate the effect of uric acid lowering therapy in reducing the new development of comorbidities and the frequency of acute attacks in gout patients. We retrospectively reviewed patients who were diagnosed to have gout with at least 3 yr of follow up. They were divided into 2 groups; 53 patients with mean serum uric acid level (sUA)<6 mg/dL and 147 patients with mean sUA≥6 mg/dL. Comorbidities of gout such as hypertension (HTN), type II diabetes mellitus (DM), chronic kidney disease, cardiovascular disease (CVD) and urolithiasis were compared in each group at baseline and at last follow-up visit. Frequency of acute gout attacks were also compared between the groups. During the mean follow up period of 7.6 yr, the yearly rate of acute attack and the new development of HTN, DM, CVD and urolithiasis was lower in the adequately treated group compared to the inadequately treated group. Tight control of uric acid decreases the incidence of acute gout attacks and comorbidities of gout such as HTN, DM, CVD and urolithiasis. |
| Author | Kwon, Seong-Ryul Joo, Kowoon Jung, Kyong-Hee Joo, Hoyeon Park, Won Lim, Mie-Jin |
| AuthorAffiliation | Division of Rheumatology, Department of Internal Medicine, Inha University Hospital, Incheon, Korea |
| AuthorAffiliation_xml | – name: Division of Rheumatology, Department of Internal Medicine, Inha University Hospital, Incheon, Korea |
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| Cites_doi | 10.1161/01.HYP.0000072820.07472.3B 10.4065/81.7.925 10.1097/00002281-200105000-00016 10.1592/phco.28.4.437 10.1002/acr.21772 10.1002/art.20405 10.1097/BOR.0b013e3283257b96 10.1016/j.amjmed.2011.09.033 10.1056/NEJM199602153340707 10.1002/art.1780200320 10.1111/j.1464-410X.1985.tb05853.x 10.1002/art.30520 10.1136/ard.2007.076182 10.1001/jama.300.8.924 10.1016/j.jbspin.2011.05.010 10.1007/s10067-006-0527-4 10.1136/annrheumdis-2013-203325 10.2337/diacare.29.03.06.dc05-1465 10.1016/0895-4356(88)90127-8 10.1159/000168799 10.1136/ard.2007.076232 10.1007/s11255-007-9253-3 10.1093/rheumatology/ken066 10.1016/j.juro.2012.11.076 10.1002/art.33483 10.1016/j.ijcard.2009.08.037 10.1093/rheumatology/ken305 10.1093/rheumatology/kes211 10.7326/0003-4819-67-6-1133 10.1016/j.berh.2010.10.004 |
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| Keywords | Hypertension Cardiovascular Diseases Renal Insufficiency Urolithiasis Comorbidity Allopurinol Gout Diabetes Mellitus |
| Language | English |
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| SubjectTerms | Adult Allopurinol - therapeutic use Antimetabolites - therapeutic use Benzbromarone - therapeutic use Cardiovascular Diseases - epidemiology Cardiovascular Diseases - prevention & control Comorbidity Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - prevention & control Enzyme Inhibitors - therapeutic use Febuxostat Female Gout - drug therapy Gout - prevention & control Gout Suppressants - therapeutic use Humans Hypertension - epidemiology Hypertension - prevention & control Male Middle Aged Original Renal Insufficiency, Chronic - epidemiology Renal Insufficiency, Chronic - prevention & control Retrospective Studies Thiazoles - therapeutic use Uric Acid - blood Uric Acid - metabolism Uricosuric Agents - therapeutic use Urolithiasis - epidemiology Urolithiasis - prevention & control 의학일반 |
| Title | Prevention of Comorbidity and Acute Attack of Gout by Uric Acid Lowering Therapy |
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