Blood pressure lowering by pioglitazone. Evidence for a direct vascular effect

• Published in: The Journal of clinical investigation Vol. 96; no. 1; pp. 354 - 360
• Main Authors: Buchanan, T A, Meehan, W P, Jeng, Y Y, Yang, D, Chan, T M, Nadler, J L, Scott, S, Rude, R K, Hsueh, W A
• Format: Journal Article
• Language: English
• Published: United States 01.07.1995
• Subjects: Animals; Antihypertensive Agents - pharmacology; Aorta - drug effects; Blood Pressure - drug effects; In Vitro Techniques; Insulin - pharmacology; Magnesium - blood; Male; Muscle, Smooth, Vascular - drug effects; Rats; Rats, Sprague-Dawley; Thiazoles - pharmacology; Thiazolidinediones

To examine potential mechanisms for the blood pressure-lowering action of the thiazolidinedione compound, pioglitazone (PIO), we studied the effects of the drug on blood pressure and insulin action in vivo and on vascular tissue in vitro. In vivo, PIO lowered blood pressure in fructose-fed and chow-...