Presence OF CXCR3-Positive Cells and IFN-γ–Producing Cells in Human Periapical Granulomas
In an attempt to understand further the balance between the types of helper T (Th) cells in human apical periodontitis, we examined the difference in the expression of the chemokine receptor and cytokine in samples obtained from human subjects by means of immunohistochemical methods. Chemokine recep...
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| Published in | Journal of endodontics Vol. 30; no. 9; pp. 634 - 637 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.09.2004
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0099-2399 1878-3554 |
| DOI | 10.1097/01.DON.0000125878.34119.3E |
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| Abstract | In an attempt to understand further the balance between the types of helper T (Th) cells in human apical periodontitis, we examined the difference in the expression of the chemokine receptor and cytokine in samples obtained from human subjects by means of immunohistochemical methods. Chemokine receptor CXCR3-positive cells and IFN-γ–producing cells were found to be present in human periapical granulomas, whereas chemokine receptor CCR3-positive cells and IL-4–producing cells could not be detected. By contrast, no factor expression was observed in a clinically healthy periodontal ligament serving as a negative control. Our findings suggest that Th1 cells may play an important role in the pathological process of local inflammation such as apical periodontitis. |
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| AbstractList | In an attempt to understand further the balance between the types of helper T (Th) cells in human apical periodontitis, we examined the difference in the expression of the chemokine receptor and cytokine in samples obtained from human subjects by means of immunohistochemical methods. Chemokine receptor CXCR3-positive cells and IFN-gamma-producing cells were found to be present in human periapical granulomas, whereas chemokine receptor CCR3-positive cells and IL-4-producing cells could not be detected. By contrast, no factor expression was observed in a clinically healthy periodontal ligament serving as a negative control. Our findings suggest that Th1 cells may play an important role in the pathological process of local inflammation such as apical periodontitis. In an attempt to understand further the balance between the types of helper T (Th) cells in human apical periodontitis, we examined the difference in the expression of the chemokine receptor and cytokine in samples obtained from human subjects by means of immunohistochemical methods. Chemokine receptor CXCR3-positive cells and IFN-gamma-producing cells were found to be present in human periapical granulomas, whereas chemokine receptor CCR3-positive cells and IL-4-producing cells could not be detected. By contrast, no factor expression was observed in a clinically healthy periodontal ligament serving as a negative control. Our findings suggest that Th1 cells may play an important role in the pathological process of local inflammation such as apical periodontitis.In an attempt to understand further the balance between the types of helper T (Th) cells in human apical periodontitis, we examined the difference in the expression of the chemokine receptor and cytokine in samples obtained from human subjects by means of immunohistochemical methods. Chemokine receptor CXCR3-positive cells and IFN-gamma-producing cells were found to be present in human periapical granulomas, whereas chemokine receptor CCR3-positive cells and IL-4-producing cells could not be detected. By contrast, no factor expression was observed in a clinically healthy periodontal ligament serving as a negative control. Our findings suggest that Th1 cells may play an important role in the pathological process of local inflammation such as apical periodontitis. In an attempt to understand further the balance between the types of helper T (Th) cells in human apical periodontitis, we examined the difference in the expression of the chemokine receptor and cytokine in samples obtained from human subjects by means of immunohistochemical methods. Chemokine receptor CXCR3-positive cells and IFN-γ–producing cells were found to be present in human periapical granulomas, whereas chemokine receptor CCR3-positive cells and IL-4–producing cells could not be detected. By contrast, no factor expression was observed in a clinically healthy periodontal ligament serving as a negative control. Our findings suggest that Th1 cells may play an important role in the pathological process of local inflammation such as apical periodontitis. |
| Author | Maeda, Katsumasa Yoneda, Masahiro Motooka, Noriko Kabashima, Hiroaki Nagata, Kengo Nakamuta, Hiroyoshi Isobe, Ryoko |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15329566$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1182/blood.V90.3.909 10.1182/blood.V95.10.3032 10.1002/jbmr.5650010511 10.4049/jimmunol.144.11.4226 10.1016/S0099-2399(06)81794-2 10.1097/00004770-200203000-00014 10.1016/S0003-9969(98)00094-6 10.1084/jem.184.3.963 10.1146/annurev.immunol.15.1.675 10.4049/jimmunol.157.4.1350 10.1172/JCI113318 10.1016/0006-291X(90)91550-C 10.1084/jem.185.3.461 10.1097/00004770-200204000-00005 10.1006/cyto.2002.1985 10.1006/cyto.2001.0947 10.1034/j.1600-0722.2000.108003195.x 10.4049/jimmunol.163.11.6236 10.1016/0167-5699(96)80606-2 10.1046/j.1365-2249.2001.01511.x 10.1016/S0167-5699(99)01469-3 10.1016/S0099-2399(06)80841-1 10.1006/cyto.2001.0879 10.1084/jem.183.6.2437 10.1182/blood.V84.7.2068.2068 10.1084/jem.184.3.799 10.1084/jem.187.12.2009 10.1172/JCI1422 10.1111/j.1600-0714.1998.tb01922.x |
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| References | Stashenko, Yu, Wang (bib2) 1992; 18 Rincon, Anguita, Nakamura, Fikrig, Flavell (bib27) 1997; 185 Kawashima, Stashenko (bib4) 1999; 44 Rollin (bib13) 1997; 90 Watanabe, Tanaka, Morimoto (bib24) 1990; 172 Gowen, Mundy (bib23) 1986; 5 Kabashima, Yoneda, Nagata (bib19) 2001; 16 Jiang, Schilder (bib5) 2002; 28 Mackay (bib11) 1996; 184 Artese, Piatteli, Quaranta, Coasante, Musiani (bib1) 1991; 17 Canalis, McCarthy, Centrella (bib7) 1998; 81 Cole, Strick, Paradis (bib14) 1998; 187 Murdoch, Finn (bib18) 2000; 95 Ponath, Qin, Post (bib10) 1996; 183 Kabashima, Yoneda, Nagata, Hirofuji, Maeda (bib21) 2002; 20 Walker, Lappin, Takahashi, Hope, Macdonald, Kinane (bib29) 2000; 108 Mantovani (bib15) 1999; 20 Mosmann, Sad (bib8) 1996; 17 Carlos, Jharlan (bib25) 1994; 84 Gemmel, Carter, Seymour (bib20) 2001; 125 Kabashima, Nagata, Maeda, Iijima (bib3) 1998; 27 Shields, Morland, Qin, Hubscher, Adam (bib17) 1999; 163 Baggiolini, Dewald, Moser (bib12) 1997; 15 Bradley, Dalton, Croft (bib26) 1996; 157 Loetscher, Gerber, Loetscher (bib9) 1996; 184 Qin, Rottman, Myers (bib16) 1998; 101 Kurihara, Bertolini, Suda, Akiyama, Roodman (bib22) 1990; 144 Kim, Lin (bib6) 2002; 28 Kabashima, Nagata, Maeda, Iijima (bib28) 2001; 14 Kabashima (R3-2) 1998; 27 Murdoch (R18-2) 2000; 95 Kabashima (R28-2) 2001; 14 Kabashima (R19-2) 2001; 16 Gemmel (R20-2) 2001; 125 Kim (R6-2) 2002; 28 Canalis (R7-2) 1998; 81 Rincon (R27-2) 1997; 185 Kurihara (R22-2) 1990; 144 Artese (R1-2) 1991; 17 Gowen (R23-2) 1986; 5 Mantovani (R15-2) 1999; 20 Stashenko (R2-2) 1992; 18 Rollin (R13-2) 1997; 90 Bradley (R26-2) 1996; 157 Walker (R29-2) 2000; 108 Mackay (R11-2) 1996; 184 Cole (R14-2) 1998; 187 Loetscher (R9-2) 1996; 184 Watanabe (R24-2) 1990; 172 Ponath (R10-2) 1996; 183 Kabashima (R21-2) 2002; 20 Kawashima (R4-2) 1999; 44 Shields (R17-2) 1999; 163 Baggiolini (R12-2) 1997; 15 Jiang (R5-2) 2002; 28 Carlos (R25-2) 1994; 84 Qin (R16-2) 1998; 101 Mosmann (R8-2) 1996; 17 |
| References_xml | – volume: 187 start-page: 2009 year: 1998 end-page: 2021 ident: bib14 article-title: Interferon-inducible T-cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T-cell through selective high affinity binding to CXCR3 publication-title: J Exp Med – volume: 108 start-page: 195 year: 2000 end-page: 201 ident: bib29 article-title: Cytokine expression in periapical granulation tissue as assessed by immunohistochemistry publication-title: Eur J Oral Sci – volume: 20 start-page: 70 year: 2002 end-page: 77 ident: bib21 article-title: The presence of chemokine (MCP-1, MIP-1α, MIP-1β, IP-10, RANTES)-positive cells and chemokine receptor (CCR5, CXCR3)-positive cells in inflamed human gingival tissues publication-title: Cytokine – volume: 183 start-page: 2437 year: 1996 end-page: 2448 ident: bib10 article-title: Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils publication-title: J Exp Med – volume: 81 start-page: 277 year: 1998 end-page: 281 ident: bib7 article-title: Growth factors and the regulation of bone remodeling publication-title: J Clin Invest – volume: 172 start-page: 1035 year: 1990 end-page: 1041 ident: bib24 article-title: Interleukin-4 as a potent inhibitor of bone resorption publication-title: Biochem Biophys Res Commun – volume: 20 start-page: 254 year: 1999 end-page: 257 ident: bib15 article-title: The chemokine system: redundancy for robust outputs publication-title: Immunol Today – volume: 184 start-page: 799 year: 1996 end-page: 802 ident: bib11 article-title: Chemokine receptors and T-cell chemotaxis publication-title: J Exp Med – volume: 18 start-page: 422 year: 1992 end-page: 426 ident: bib2 article-title: Kinetics of immune cell and bone resorptive response to endodontics infections publication-title: J Endod – volume: 163 start-page: 6236 year: 1999 end-page: 6243 ident: bib17 article-title: Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver publication-title: J Immunol – volume: 95 start-page: 3032 year: 2000 end-page: 3043 ident: bib18 article-title: Chemokine receptors and their role in inflammation and infectious disease publication-title: Blood – volume: 184 start-page: 963 year: 1996 end-page: 969 ident: bib9 article-title: Chemokine receptor specific for IP-10 and mig: structure, function, and expression in activated T-lymphocytes publication-title: J Exp Med – volume: 28 start-page: 279 year: 2002 end-page: 282 ident: bib5 article-title: An optimal host response to a bacterium may require the interaction of leukocytes and resident host cells publication-title: J Endod – volume: 101 start-page: 746 year: 1998 end-page: 754 ident: bib16 article-title: The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions publication-title: J Clin Invest – volume: 84 start-page: 2068 year: 1994 end-page: 2101 ident: bib25 article-title: Leukocyte-endothelial adhesion molecules publication-title: Blood – volume: 144 start-page: 4226 year: 1990 end-page: 4230 ident: bib22 article-title: IL-6 stimulates osteoclast-like multinucleated cell formation in long term human morrow cultures by inducing IL-1 release publication-title: J Immunol – volume: 90 start-page: 909 year: 1997 end-page: 928 ident: bib13 article-title: Chemokines publication-title: Blood – volume: 16 start-page: 62 year: 2001 end-page: 66 ident: bib19 article-title: The presence of chemokine receptor (CXCR3, CCR5, CCR3)-positive cells and chemokine (MCP-1, MIP-1α, MIP-1β, IP-10)-positive cells in human periapical granulomas publication-title: Cytokine – volume: 17 start-page: 138 year: 1996 end-page: 146 ident: bib8 article-title: The expanding universe of T-cell subsets: Th publication-title: Immunol Today – volume: 5 start-page: 469 year: 1986 end-page: 474 ident: bib23 article-title: Preferential inhibition of cytokine-stimulated bone resorption by recombinant interferon-γ publication-title: J Bone Miner Res – volume: 17 start-page: 483 year: 1991 end-page: 487 ident: bib1 article-title: Immunoreactivity for interleukin-1β and tumor necrosis factor-α and ultrastructural features of monocytes/macrophages in periapical granulomas publication-title: J Endod – volume: 185 start-page: 461 year: 1997 end-page: 469 ident: bib27 article-title: Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4 publication-title: J Exp Med – volume: 27 start-page: 95 year: 1998 end-page: 100 ident: bib3 article-title: Interferon-γ producing cells and inducible nitric oxide synthase producing cells in the periapical granuloma publication-title: J Oral Pathol Med – volume: 28 start-page: 202 year: 2002 end-page: 205 ident: bib6 article-title: T lymphocyte subpopulations and interleukin-2, interferon-gamma, and interleukin-4 in rat pulpitis experimentally induced by specific bacteria publication-title: J Endod – volume: 157 start-page: 1350 year: 1996 end-page: 1358 ident: bib26 article-title: A direct role for IFN-γ in regulation of Th1 cell development publication-title: J Immunol – volume: 44 start-page: 55 year: 1999 end-page: 66 ident: bib4 article-title: Expression of bone-resorptive and regulatory cytokines in murine periapical inflammation publication-title: Arch Oral Biol – volume: 15 start-page: 675 year: 1997 end-page: 705 ident: bib12 article-title: Human chemokines: an update publication-title: Annu Rev Immunol – volume: 125 start-page: 134 year: 2001 end-page: 141 ident: bib20 article-title: Chemokines in human periodontal disease tissues publication-title: Clin Exp Immunol – volume: 14 start-page: 289 year: 2001 end-page: 293 ident: bib28 article-title: Presence of IFN-γ and IL-4 in human periapical granulation tissues and regeneration tissues publication-title: Cytokine – volume: 90 start-page: 909 year: 1997 ident: R13-2 publication-title: Blood doi: 10.1182/blood.V90.3.909 – volume: 95 start-page: 3032 year: 2000 ident: R18-2 publication-title: Blood doi: 10.1182/blood.V95.10.3032 – volume: 5 start-page: 469 year: 1986 ident: R23-2 publication-title: J Bone Miner Res doi: 10.1002/jbmr.5650010511 – volume: 144 start-page: 4226 year: 1990 ident: R22-2 publication-title: J Immunol doi: 10.4049/jimmunol.144.11.4226 – volume: 17 start-page: 483 year: 1991 ident: R1-2 publication-title: J Endod doi: 10.1016/S0099-2399(06)81794-2 – volume: 28 start-page: 202 year: 2002 ident: R6-2 publication-title: J Endod doi: 10.1097/00004770-200203000-00014 – volume: 44 start-page: 55 year: 1999 ident: R4-2 publication-title: Arch Oral Biol doi: 10.1016/S0003-9969(98)00094-6 – volume: 184 start-page: 963 year: 1996 ident: R9-2 publication-title: J Exp Med doi: 10.1084/jem.184.3.963 – volume: 15 start-page: 675 year: 1997 ident: R12-2 publication-title: Annu Rev Immunol doi: 10.1146/annurev.immunol.15.1.675 – volume: 157 start-page: 1350 year: 1996 ident: R26-2 publication-title: J Immunol doi: 10.4049/jimmunol.157.4.1350 – volume: 81 start-page: 277 year: 1998 ident: R7-2 publication-title: J Clin Invest doi: 10.1172/JCI113318 – volume: 172 start-page: 1035 year: 1990 ident: R24-2 publication-title: Biochem Biophys Res Commun doi: 10.1016/0006-291X(90)91550-C – volume: 185 start-page: 461 year: 1997 ident: R27-2 publication-title: J Exp Med doi: 10.1084/jem.185.3.461 – volume: 28 start-page: 279 year: 2002 ident: R5-2 publication-title: J Endod doi: 10.1097/00004770-200204000-00005 – volume: 20 start-page: 70 year: 2002 ident: R21-2 publication-title: Cytokine doi: 10.1006/cyto.2002.1985 – volume: 16 start-page: 62 year: 2001 ident: R19-2 publication-title: Cytokine doi: 10.1006/cyto.2001.0947 – volume: 108 start-page: 195 year: 2000 ident: R29-2 publication-title: Eur J Oral Sci doi: 10.1034/j.1600-0722.2000.108003195.x – volume: 163 start-page: 6236 year: 1999 ident: R17-2 publication-title: J Immunol doi: 10.4049/jimmunol.163.11.6236 – volume: 17 start-page: 138 year: 1996 ident: R8-2 publication-title: Immunol Today doi: 10.1016/0167-5699(96)80606-2 – volume: 125 start-page: 134 year: 2001 ident: R20-2 publication-title: Clin Exp Immunol doi: 10.1046/j.1365-2249.2001.01511.x – volume: 20 start-page: 254 year: 1999 ident: R15-2 publication-title: Immunol Today doi: 10.1016/S0167-5699(99)01469-3 – volume: 18 start-page: 422 year: 1992 ident: R2-2 publication-title: J Endod doi: 10.1016/S0099-2399(06)80841-1 – volume: 14 start-page: 289 year: 2001 ident: R28-2 publication-title: Cytokine doi: 10.1006/cyto.2001.0879 – volume: 183 start-page: 2437 year: 1996 ident: R10-2 publication-title: J Exp Med doi: 10.1084/jem.183.6.2437 – volume: 84 start-page: 2068 year: 1994 ident: R25-2 publication-title: Blood doi: 10.1182/blood.V84.7.2068.2068 – volume: 184 start-page: 799 year: 1996 ident: R11-2 publication-title: J Exp Med doi: 10.1084/jem.184.3.799 – volume: 187 start-page: 2009 year: 1998 ident: R14-2 publication-title: J Exp Med doi: 10.1084/jem.187.12.2009 – volume: 101 start-page: 746 year: 1998 ident: R16-2 publication-title: J Clin Invest doi: 10.1172/JCI1422 – volume: 27 start-page: 95 year: 1998 ident: R3-2 publication-title: J Oral Pathol Med doi: 10.1111/j.1600-0714.1998.tb01922.x |
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| SubjectTerms | Adult Humans Interferon-Stimulated Gene Factor 3 Male Middle Aged Periapical Granuloma - immunology Periapical Granuloma - pathology Receptors, Chemokine - analysis Receptors, CXCR3 Th1 Cells - immunology Th2 Cells - immunology Transcription Factors - analysis |
| Title | Presence OF CXCR3-Positive Cells and IFN-γ–Producing Cells in Human Periapical Granulomas |
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