The effect of Trimetazidine and Diazoxide on immunomodulatory activity of human embryonic stem cell-derived mesenchymal stem cell secretome

• Published in: Tissue & cell Vol. 49; no. 5; pp. 597 - 602
• Main Authors: Jahandideh, Saeed, Maghsood, Faezeh, Ghahhari, Nastaran Mohammadi, Lotfinia, Majid, Mohammadi, Mohammad, Johari, Behrooz, Kadivar, Mehdi
• Format: Journal Article
• Language: English
• Published: Scotland Elsevier Ltd 01.10.2017; Elsevier Science Ltd
• Subjects: Cell cycle; Cell growth; Chemokines; Conditioning; Culture Media, Conditioned; Cytokines; Diazoxide; Diazoxide - pharmacology; Embryo cells; Embryonic stem cell-derived mesenchymal stem cells; Embryonic Stem Cells - drug effects; Enzyme-linked immunosorbent assay; Extracellular matrix; Growth factors; Hematopoiesis; Humans; Immune response; Immune system; Immunomodulation; Immunosuppressive agents; Interleukin 10; Interleukin-10 - secretion; Interleukin-1beta - secretion; Leukocytes (mononuclear); Leukocytes, Mononuclear - drug effects; Leukocytes, Mononuclear - secretion; Lipopolysaccharides; Mesenchymal Stem Cell Transplantation - methods; Mesenchymal Stromal Cells - drug effects; Mesenchyme; Peripheral blood mononuclear cells; Pharmacology; Preconditioning; Proteins; Proteome - drug effects; Proteomes; Regeneration; Secretome; Stem cells; Therapeutic applications; Transplantation; Trimetazidine; Trimetazidine - pharmacology; Tumor Necrosis Factor-alpha - secretion; Tumor necrosis factor-α; Vascularization; Vasodilator Agents - pharmacology; Secretome; Diazoxide; Preconditioning; Trimetazidine; Embryonic stem cell-derived mesenchymal stem cells

•Thanks to the greater expansion capability compared to regular MSCs, ESC-MSCs are better candidate for secretome therapy.•TMZ and DZ- ESC-MSCs conditioned medium increased the secretion of IL-10, TNFα and IL-1β from LPS- induced PBMCs.•TMZ and DZ can be used to modulate the immune-activity effects...