Decoding the Clinical Significance of Immunoglobulin G4 in Rheumatoid Arthritis

• Published in: Journal of clinical medicine Vol. 12; no. 14; p. 4716
• Main Authors: Tan, Li Fen, Sakthiswary, Rajalingham, Veshaaliini, Uma Rajeswaran, Shaharir, Syahrul Sazliyana, Wahab, Asrul Abdul, Aziz, Suraya, Sutan, Rosnah
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.07.2023; MDPI
• Subjects: Antigens; Arthritis; Autoimmune diseases; Care and treatment; Clinical medicine; Clinical significance; Correlation analysis; Disease; Immunoglobulin G; Immunoglobulins; Lupus; Medical research; Medicine, Experimental; Patients; Population; Remission (Medicine); Rheumatoid arthritis; Rheumatoid factor; Rheumatology; Sociodemographics; Software; Variables; Malaysia; United States > US; disease activity; joint damage; functional disability; immunoglobulin G4; rheumatoid arthritis; treatment response

Immunoglobulin (Ig) G4 accounts for 4–6% of the total IgG in a healthy human. Several evidence-based studies have suggested that the level of IgG4 is significantly elevated in autoimmune diseases, including rheumatoid arthritis (RA). The clinical significance of IgG4 in RA with regard to disease act...