Blocking histone deacetylase activity as a novel target for epithelial barrier defects in patients with allergic rhinitis

• Published in: Journal of allergy and clinical immunology Vol. 144; no. 5; pp. 1242 - 1253.e7
• Main Authors: Steelant, Brecht, Wawrzyniak, Paulina, Martens, Katleen, Jonckheere, Anne-Charlotte, Pugin, Benoit, Schrijvers, Rik, Bullens, Dominique M., Vanoirbeek, Jeroen A., Krawczyk, Krzysztof, Dreher, Anita, Akdis, Cezmi A., Hellings, Peter W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2019; Elsevier Limited
• Subjects: Allergic rhinitis; Asthma; Defects; Dextran; DNA methylation; epigenetic changes; Epigenetics; Epithelial cells; Fluorescein isothiocyanate; Gene expression; Genes; Histone deacetylase; Hyperreactivity; Hypersensitivity; Immunofluorescence; Inflammation; Membrane permeability; Mucosa; Permeability; primary nasal epithelial cells; Proteins; Respiratory tract diseases; Tight junctions; Belgium; Germany; TER; TSLP; DAPI; FP; histone deacetylase; BAL; HDM; AR; ZO-1; Allergic rhinitis; epigenetic changes; tight junctions; primary nasal epithelial cells; ALI; HDAC
• ISSN: 0091-6749; 1097-6825; 1097-6825
• DOI: 10.1016/j.jaci.2019.04.027

A defective epithelial barrier is found in patients with allergic rhinitis (AR) and asthma; however, the underlying mechanisms remain poorly understood. Histone deacetylase (HDAC) activity has been identified as a crucial driver of allergic inflammation and tight junction dysfunction. We investigate...