Blocking histone deacetylase activity as a novel target for epithelial barrier defects in patients with allergic rhinitis - Steelant, Brecht; Wawrzyniak, Paulina; Martens, Katleen; Jonckheere, Anne-Charlotte; Pugin, Benoit; Schrijvers, Rik; Bullens, Dominique M.; Vanoirbeek, Jeroen A.; Krawczyk, Krzysztof; Dreher, Anita; Akdis, Cezmi A.; Hellings, Peter W. (Journal of allergy and clinical immunology, 2019)
Keywords: Allergic rhinitis; Asthma; Defects; Dextran; DNA methylation; epigenetic changes; Epigenetics; Epithelial cells; Fluorescein isothiocyanate; Gene expression; Genes; Histone deacetylase; Hyperreactivity; Hypersensitivity; Immunofluorescence; Inflammation; Membrane permeability; Mucosa; Permeability; primary nasal epithelial cells; Proteins; Respiratory tract diseases; Tight junctions; Belgium; Germany; TER; TSLP; DAPI; FP; histone deacetylase; BAL; HDM; AR; ZO-1; Allergic rhinitis; epigenetic changes; tight junctions; primary nasal epithelial cells; ALI; HDAC