Lipoprotein cholesteryl ester production, transfer, and output in vivo in humans

• Published in: Journal of lipid research Vol. 45; no. 9; pp. 1594 - 1607
• Main Authors: Schwartz, Charles C., VandenBroek, Julie M., Cooper, Patricia S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier 01.09.2004
• Subjects: Adult; Aged; Aged, 80 and over; Biological Transport - physiology; cholesterol; Cholesterol - blood; Cholesterol Esters - biosynthesis; Cholesterol Esters - metabolism; Evolution, Molecular; Female; high density lipoprotein; Humans; kinetics; Lipoproteins - biosynthesis; Lipoproteins - metabolism; Lipoproteins, HDL - metabolism; Lipoproteins, IDL; Lipoproteins, LDL - metabolism; Lipoproteins, VLDL - metabolism; Liver - metabolism; low density lipoprotein; Male; Mevalonic Acid - metabolism; Middle Aged; Models, Biological; reverse transport

Our aim was to identify and quantify the major in vivo pathways of lipoprotein cholesteryl ester transport in humans. Normal (n = 7), bile fistula (n = 5), and familial hypercholesterolemia (FH; n = 1) subjects were studied. Each received isotopic free cholesterol in HDL, LDL, or particulate form, a...