Gemcitabine delivered by fucoidan/chitosan nanoparticles presents increased toxicity over human breast cancer cells

• Published in: Nanomedicine (London, England) Vol. 13; no. 16; pp. 2037 - 2050
• Main Authors: Oliveira, Catarina, Neves, Nuno M, Reis, Rui L, Martins, Albino, Silva, Tiago H
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.08.2018
• Subjects: Antineoplastic Agents - administration & dosage; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Breast cancer; breast cancer cells; Breast Neoplasms - metabolism; Cancer therapies; Cell Line; Cell Line, Tumor; Cell Survival - drug effects; chitosan; Chitosan - chemistry; Cytotoxicity; Deoxycytidine - administration & dosage; Deoxycytidine - analogs & derivatives; Deoxycytidine - chemistry; Deoxycytidine - pharmacology; Drug delivery systems; Drug Delivery Systems - methods; drug-delivery system; Drugs; endothelial cells; Endothelial Cells - drug effects; fucoidan; gemcitabine; Humans; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Nanoparticles; Nanoparticles - chemistry; Nanoparticles - ultrastructure; polyelectrolyte complexation; Polymers; Polymers - chemistry; Polysaccharides - chemistry; United Kingdom > UK; United States > US; breast cancer cells; chitosan; endothelial cells; nanoparticles; drug-delivery system; gemcitabine; fucoidan; polyelectrolyte complexation

To produce marine-origin nanoparticles (NPs) aiming to develop more effective and tolerated therapies for breast cancer. NPs based in two marine-origin polymers (fucoidan and chitosan) were prepared by polyelectrolyte complexation, for the delivery of an antitumor drug model (gemcitabine [Gem]). Fin...