The Compartmentalization of Amyloid-β in Idiopathic Normal Pressure Hydrocephalus Brain Biopsies

• Published in: Journal of Alzheimer's disease Vol. 99; no. 2; pp. 729 - 737
• Main Authors: Libard, Sylwia, Hodik, Monika, Cesarini, Kristina Giuliana, Dragomir, Anca, Alafuzoff, Irina
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 14.05.2024
• Subjects: amyloid-β; Alzheimer’s disease neuropathological change; Alzheimer’s disease; idiopathic normal pressure hydrocephalus

Background: Amyloid-β (Aβ) is one of the hallmark lesions of Alzheimer’s disease (AD). During the disease process, Aβ undergoes biochemical changes, producing toxic Aβ variants, proposed to be detected within the neurons. Idiopathic normal pressure hydrocephalus (iNPH) causes cognitive impairment, g...