Antigen presentation under the influence of ‘immune evasion’ proteins and its modulation by interferon-gamma: implications for immunotherapy of cytomegalovirus infection with antiviral CD8 T cells

• Published in: Medical microbiology and immunology Vol. 201; no. 4; pp. 513 - 525
• Main Authors: Fink, Annette, Lemmermann, Niels A. W., Gillert-Marien, Dorothea, Thomas, Doris, Freitag, Kirsten, Böhm, Verena, Wilhelmi, Vanessa, Reifenberg, Kurt, Reddehase, Matthias J., Holtappels, Rafaela
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.11.2012; Springer; Springer Nature B.V
• Subjects: Adoptive Transfer; Animals; Antigen Presentation; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer therapies; CD8-Positive T-Lymphocytes - immunology; Cytomegalovirus; Cytomegalovirus - immunology; Cytomegalovirus - pathogenicity; Cytomegalovirus Infections - immunology; Cytomegalovirus Infections - therapy; Disease Models, Animal; Fundamental and applied biological sciences. Psychology; Immune Evasion; Immunology; Immunotherapy; Interferon-gamma - immunology; Medical Microbiology; Mice; Mice, Inbred BALB C; Mice, Transgenic; Microbiology; Miscellaneous; Murine cytomegalovirus; Original Investigation; T cell receptors; Treatment Outcome; Virology; Viruses; Antigen presentation; Cytomegalovirus; IFN-γ transgenic mice; Interferon-γ; Immunotherapy; MHC class I; Immune evasion; Hematopoietic cell transplantation (HCT); CD8 T cells; IFN-y transgenic mice; Transgenic animal; Hematopoietic cell; Transplantation; Betaherpesvirinae; Immunology; Antiviral; Class I histocompatibility antigen; CD8 T lymphocyte; Herpesviridae; Cytokine; Rodentia; Protein; Infection; Virus; Vertebrata; Mammalia; Mouse; Viral disease; Gamma interferon

Cytomegalovirus (CMV) disease with multiple organ manifestations is the most feared viral complication limiting the success of hematopoietic cell transplantation as a therapy of hematopoietic malignancies. A timely endogenous reconstitution of CD8 T cells controls CMV infection, and adoptive transfe...