Prediction of peptide binding to MHC using machine learning with sequence and structure-based feature sets

• Published in: Biochimica et biophysica acta. General subjects Vol. 1864; no. 4; p. 129535
• Main Authors: Aranha, Michelle P., Spooner, Catherine, Demerdash, Omar, Czejdo, Bogdan, Smith, Jeremy C., Mitchell, Julie C.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2020; Elsevier
• Subjects: BASIC BIOLOGICAL SCIENCES; Binding affinity; Machine learning; MHC-peptide; Machine learning; Binding affinity; MHC-peptide

Selecting peptides that bind strongly to the major histocompatibility complex (MHC) for inclusion in a vaccine has therapeutic potential for infections and tumors. Machine learning models trained on sequence data exist for peptide:MHC (p:MHC) binding predictions. Here, we train support vector machin...