Protective Effects of Long-Term Escitalopram Administration on Memory and Hippocampal BDNF and BCL-2 Gene Expressions in Rats Exposed to Predictable and Unpredictable Chronic Mild Stress

• Published in: Brain sciences Vol. 14; no. 5; p. 420
• Main Authors: Saedi Marghmaleki, Vajihe, Radahmadi, Maryam, Alaei, Hojjatallah, Khanahmad, Hossein
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.04.2024
• Subjects: Animal cognition; Apoptosis; BCL-2; Bcl-2 protein; BDNF; Brain-derived neurotrophic factor; Citalopram; Drug dosages; Employment; escitalopram; Gene expression; Hippocampus; Latency; Light; Medical research; Memory; Neurogenesis; predictable stress; Serotonin; Stress; unpredictable stress; Iran; BCL-2; escitalopram; predictable stress; unpredictable stress; memory; BDNF

Stress and escitalopram (an anti-stress medication) can affect brain functions and related gene expression. This study investigated the protective effects of long-term escitalopram administration on memory, as well as on hippocampal BDNF and BCL-2 gene expressions in rats exposed to predictable and...