Upregulated TRIM11 Exerts its Oncogenic Effects in Hepatocellular Carcinoma Through Inhibition of P53

• Published in: Cellular physiology and biochemistry Vol. 44; no. 1; pp. 255 - 266
• Main Authors: Liu, Jinjin, Rao, Jun, Lou, Xuming, Zhai, Jian, Ni, Zhenhua, Wang, Xiongbiao
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Cell Physiol Biochem Press GmbH & Co KG 01.01.2017
• Subjects: Animals; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Movement; Cell Proliferation; Cyclin D1 - genetics; Cyclin D1 - metabolism; Cyclin-Dependent Kinase Inhibitor p21 - genetics; Cyclin-Dependent Kinase Inhibitor p21 - metabolism; Cyclin-Dependent Kinase Inhibitor p27 - genetics; Cyclin-Dependent Kinase Inhibitor p27 - metabolism; Down-Regulation; Epithelial-Mesenchymal Transition; HCC; Hep G2 Cells; Humans; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Mice; Mice, Inbred BALB C; Mice, Nude; Original Paper; P53; Progression; Real-Time Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering - metabolism; Transplantation, Heterologous; Trim11; Tripartite Motif Proteins - antagonists & inhibitors; Tripartite Motif Proteins - genetics; Tripartite Motif Proteins - metabolism; Tumor growth; Tumor Suppressor Protein p53 - antagonists & inhibitors; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Ubiquitin-Protein Ligases - antagonists & inhibitors; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; Up-Regulation; Progression; HCC; Tumor growth; Trim11; P53

Background/Aims: The tripartite motif containing (TRIM) family plays crucial roles in tumor development and progression. However, little is known about the function and mechanism of TRIM11 in hepatocellular carcinoma (HCC). Methods: The expression levels of TRIM11 were examined by real-time PCR, Wes...