Novel Germline BRCA1 and BRCA2 Mutations in Turkish Women with Breast and/or Ovarian Cancer and Their Relatives

• Published in: Cancer investigation Vol. 24; no. 5; pp. 484 - 491
• Main Authors: Egeli, Unal, Cecener, Gulsah, Tunca, Berrin, Tasdelen, Ismet
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.01.2006; Taylor & Francis
• Subjects: Adult; Aged; Aged, 80 and over; Base Sequence; BRCA1 and BRCA2 genes; BRCA1 Protein - genetics; BRCA2 Protein - genetics; Breast cancer; Breast Neoplasms - genetics; Family; Female; Gene Frequency; Genetic Predisposition to Disease; Germ-Line Mutation; Heterozygote; Humans; Middle Aged; Models, Genetic; Molecular Sequence Data; Novel mutation; Ovarian cancer; Ovarian Neoplasms - genetics; Polymorphism, Genetic; Risk Assessment; Software; Turkey; Turkish population; Turkey

BRCA1 and BRCA2 gene mutations in patients with breast and/or ovarian cancer have been not characterized in the Turkish population until now. A total of 87 female subjects from two sets of families (38 families total) provided blood samples from which DNA was extracted. All coding exons of the BRCA1...