Deficiency of the planar cell polarity protein Vangl2 in podocytes affects glomerular morphogenesis and increases susceptibility to injury

• Published in: Journal of the American Society of Nephrology Vol. 26; no. 3; pp. 576 - 586
• Main Authors: Rocque, Brittany L, Babayeva, Sima, Li, Jane, Leung, Vicki, Nezvitsky, Lisa, Cybulsky, Andrey V, Gros, Philippe, Torban, Elena
• Format: Journal Article
• Language: English
• Published: United States American Society of Nephrology 01.03.2015
• Subjects: Animals; Basic Research; Cell Polarity; Female; Kidney Glomerulus - embryology; Kidney Glomerulus - physiology; Male; Mice, Inbred C57BL; Mice, Transgenic; Morphogenesis; Nerve Tissue Proteins - metabolism; Podocytes - metabolism; genetics and development; kidney development; glomerular disease

The planar cell polarity (PCP) signaling pathway is crucial for tissue morphogenesis. Van Gogh-like protein 2 (Vangl2) is central in the PCP pathway; in mice, Vangl2 loss is embryonically lethal because of neural tube defects, and mutations in Vangl2 are associated with human neural tube defects. In...