Nafamostat Mesilate Attenuates Ischemia-Reperfusion–Induced Renal Injury

• Published in: Transplantation proceedings Vol. 48; no. 6; pp. 2192 - 2199
• Main Authors: Na, K.-R, Choi, H, Jeong, J.Y, Lee, K.W, Chang, Y.-K, Choi, D.E
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2016
• Subjects: Acute Kidney Injury - prevention & control; Animals; Anticoagulants - administration & dosage; Apoptosis - drug effects; Blood Urea Nitrogen; Deoxyguanosine - analogs & derivatives; Disease Models, Animal; Guanidines - administration & dosage; In Situ Nick-End Labeling; Ischemic Preconditioning - methods; Kidney - blood supply; Kidney - drug effects; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type III - metabolism; Renal Artery - drug effects; Renal Artery - injuries; Reperfusion Injury - prevention & control; Surgery

Abstract Background It has been reported that nafamostat mesilate (NM) inhibits inflammatory injury via inhibition of complement activation in ischemic heart, liver, and intestine. However, it is unclear if NM also inhibits apoptosis in ischemia-reperfusion (IR)–injured kidney. We therefore investig...