Core Outcome Measures in Preclinical Assessment of Candidate Analgesics

• Published in: Pharmacological reviews Vol. 71; no. 2; pp. 225 - 266
• Main Author: Negus, S. Stevens
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2019; The American Society for Pharmacology and Experimental Therapeutics
• Subjects: Analgesics - pharmacology; Animals; Behavior, Animal - drug effects; Conditioning, Operant - drug effects; Disease Models, Animal; Drug Discovery - methods; Drug Evaluation, Preclinical - methods; Humans; Outcome Assessment, Health Care; Pain - drug therapy; Review; CP55940; CPP; PS; U50,488; AMG9810; NSAID; THC; CR; CS; GR89696; SC; MK-801; SD; PAD; R; U69,593; CPA; ICSS; NMDA; WIN55212-2; UR; US; CFA

All preclinical procedures for analgesic drug discovery involve two components: 1) a “pain stimulus” (the principal independent variable), which is delivered to an experimental subject with the intention of producing a pain state; and 2) a “pain behavior” (the principal dependent variable), which is...