Management of NSAID-Induced Gastrointestinal Toxicity Focus on Proton Pump Inhibitors

• Published in: Drugs (New York, N.Y.) Vol. 69; no. 1; pp. 51 - 69
• Main Authors: Lazzaroni, Marco, Porro, Gabriele Bianchi
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 2009; Adis International; Wolters Kluwer Health, Inc; Springer Nature B.V
• Subjects: Anti-Inflammatory Agents, Non-Steroidal - adverse effects; Anticoagulants; Arthritis; Aspirin; Biological and medical sciences; Bones, joints and connective tissue. Antiinflammatory agents; Clinical trials; Clinical Trials as Topic; Cohort analysis; Complications and side effects; Digestive system; Dosage and administration; Drug dosages; Drug therapy; Drug toxicity and drugs side effects treatment; Gastrointestinal diseases; Gastrointestinal Diseases - chemically induced; Gastrointestinal Diseases - drug therapy; Gastrointestinal Diseases - prevention & control; Helicobacter Infections - drug therapy; Helicobacter pylori; Helicobacter pylori - drug effects; Humans; Internal Medicine; Medical sciences; Medicine & Public Health; Mortality; Nonsteroidal anti-inflammatory drugs; Pharmacology. Drug treatments; Pharmacology/Toxicology; Pharmacotherapy; Prevention; Proton pump inhibitors; Proton Pump Inhibitors - pharmacology; Proton Pump Inhibitors - therapeutic use; Risk Factors; Steroids; Therapy in Practice; Time Factors; Toxicity; Toxicity: digestive system; Ulcers; Italy; Omeprazole; Celecoxib; Lansoprazole; Proton Pump Inhibitor; Ranitidine; Human; Stomach; Digestive system; Toxicity; Gut; Review; Pharmacovigilance; Gastrointestinal; Proton pump inhibitor; Non steroidal antiinflammatory agent; Clinical management; Secondary effect; Bibliographic review

The association between NSAIDs and the presence of upper gastrointestinal (GI) complications is well established. Evidence that acid aggravates NSAID-induced injury provides a rationale for minimizing such damage by acid suppression. Proton pump inhibitors (PPIs) appear to be very effective in treat...