Targeting Bone Tumours with 45S5 Bioactive Glass

• Published in: International journal of molecular sciences Vol. 25; no. 19; p. 10830
• Main Authors: Fellenberg, Joerg, Losch, Sarina, Arango-Ospina, Marcela, Hildenbrand, Nina, Tripel, Elena, Deng, Lingyun, Renkawitz, Tobias, Westhauser, Fabian, Lehner, Burkhard, Boccaccini, Aldo R
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.10.2024; MDPI
• Subjects: Animals; bioactive glass; Biological activity; Bone cancer; Bone Neoplasms - pathology; Bone Neoplasms - therapy; Bone tumors; Calcium compounds; Care and treatment; Cell Line, Tumor; Cell Survival - drug effects; Ceramics; chondrosarcoma; Chondrosarcoma - pathology; Chondrosarcoma - therapy; chorioallantoic membrane assay; Cytotoxicity; Etching; FDA approval; Giant Cell Tumor of Bone - pathology; Giant Cell Tumor of Bone - therapy; giant cell tumour of bone; Glass - chemistry; Health aspects; Humans; Kinases; Medical prognosis; Nanoparticles; osteosarcoma; Osteosarcoma - pathology; Osteosarcoma - therapy; Particle size; Polymers in medicine; Silica; therapy; Tissue engineering; Tumors; Germany; chondrosarcoma; giant cell tumour of bone; bioactive glass; chorioallantoic membrane assay; therapy; osteosarcoma

Despite advances in treatment modalities, bone tumour therapies still face significant challenges. Severe side effects of conventional approaches, such as chemo- and radiation therapy, result in poor survival rates and high tumour recurrence rates, which are the most common issues that need to be im...